Eltrombopag tablet and preparation method thereof

Abstract

The invention provides a preparation method of an eltrombopag tablet, belongs to the field of medicine new technologies, and relates to the eltrombopag tablet and the preparation method of the eltrombopag tablet. Eltrombopag serves as the main component of the tablet, and the tablet can be used for treating skin and skin tissue infection caused by gram-positive bacteria.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the preparation of tedizolid phosphate tablets. Background technique [0002] In 2014, the U.S. FDA approved tedizolid phosphate tablets (200mg), produced and marketed by Carbister Pharmaceuticals, an oxazolidinone antibiotic, suitable for skin and skin tissue infections caused by Gram-positive bacteria . [0003] Tedizolid phosphate is specifically targeted by Gram-positive bacteria, including: Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-sensitive [MSSA] strains), Streptococcus pyogenes, Streptococcus agalactiae , Streptococcus angina group (including Streptococcus angina, Streptococcus intermedius, and Streptococcus stellatus) and infections caused by Enterococcus faecalis. Tedizolid is the second product of Zyvox, which was launched by Pfizer in 2000 ? (Linezolid, Linezolid) is a new member of the oxazolidinone class of antibi...

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Problems solved by technology

Chinese patent CN201410840833.9 describes a preparation method of tedizolid phosphate intermediate. The tedizolid phosphate disodium salt prepared by this method has low hygroscopicity, excellent stability and purity, and improves the hygroscopicity of solid preparations. strong question

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