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Ion-covalent double-network hydrogel and preparation method thereof

A hydrogel and double-network technology, applied in the field of ion-covalent double-network hydrogel and its preparation, can solve the problems of limited application and achieve good anti-swelling performance

Active Publication Date: 2016-04-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the ioncovalent double network hydrogel prepared by one-step method is prone to generate a large number of air bubbles, which will greatly limit its practical application.

Method used

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  • Ion-covalent double-network hydrogel and preparation method thereof
  • Ion-covalent double-network hydrogel and preparation method thereof
  • Ion-covalent double-network hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Mix 6.222g of acrylamide, 0.778g of sodium carboxymethylcellulose with a degree of substitution of 1.2, 0.024g of potassium persulfate, and 5.4mg of N,N'-methylenebisacrylamide into a 50mL aqueous solution, stir and mix evenly, and add dropwise 23μL N,N,N',N'-Tetramethylethylenediamine (TEMED), stir and mix evenly, transfer the prepared prepolymer solution to a mold composed of silicone rubber and glass sheet with a thickness of 2mm, and react at 50°C for 3 The semi-interpenetrating network hydrogel can be obtained within hours. Soak this semi-IPN hydrogel in 50mL of 0.10mol / L iron ion solution for 24 hours, then soak the hydrogel soaked in iron ions in deionized water for 48 hours to obtain the covalent Double network hydrogel. The stress-strain curve figure of ioncovalent double network hydrogel obtained in the present embodiment is as follows figure 1 shown. Depend on figure 1 It can be seen that the ioncovalent double network hydrogel obtained in the present inv...

Embodiment 2

[0034] 10.222g of acrylamide, 1.278g of sodium carboxymethylcellulose with a degree of substitution of 1.2, 0.039g of potassium persulfate, and 22.1mg of N,N'-methylenebisacrylamide were made into a 50mL aqueous solution, and after mixing evenly, dropwise added 38μL N,N,N',N'-Tetramethylethylenediamine (TEMED), stir and mix evenly, transfer the prepared prepolymer solution to a mold composed of silicone rubber and glass sheet with a thickness of 2mm, and react at 50°C for 3 The semi-interpenetrating network hydrogel can be obtained within hours. Soak this semi-IPN hydrogel in 50mL of 0.50mol / L iron ion solution for 24 hours, then soak the hydrogel soaked in iron ions in deionized water for 48 hours to obtain the covalent Double network hydrogel. The stress-strain curve figure of ioncovalent double network hydrogel obtained in the present embodiment is as follows figure 2 shown. Depend on figure 2 It can be seen that the ioncovalent double network hydrogel obtained in the...

Embodiment 3

[0036] Mix 6.222g of acrylamide, 0.778g of sodium carboxymethylcellulose with degrees of substitution of 0.7, 0.9 and 1.2, 0.024g of potassium persulfate, and 5.4mg of N,N'-methylenebisacrylamide into a 50mL aqueous solution, stir and mix After uniformity, add 23 μL N,N,N',N'-tetramethylethylenediamine (TEMED) dropwise, stir and mix evenly, and then transfer the prepared prepolymer solution to a mold composed of silicone rubber and glass sheet with a thickness of 2mm The semi-interpenetrating network hydrogel can be obtained by reacting at 50°C for 3 hours. Soak this semi-IPN hydrogel in 50mL of 0.10mol / L iron ion solution for 24 hours, then soak the hydrogel soaked in iron ions in deionized water for 48 hours to obtain the covalent Double network hydrogel. The stress-strain curves of three kinds of ioncovalent double network hydrogels with different degrees of substitution obtained in this example are as follows: image 3 shown. Depend on image 3It can be seen that the t...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses an ion-covalent double-network hydrogel and a preparation method thereof. The preparation method comprises the steps that sodium carboxymethylcellulose, acrylamide, a chemical crosslinking agent and a water-soluble initiator are stirred to be mixed evenly, then a catalyst is added, the mixed materials are stirred to be mixed evenly to obtain a pre-polymerization solution, the pre-polymerization solution is poured into a mold, and a reaction is performed at room temperature to obtain a semi-interpenetrating network hydrogel; the obtained semi-interpenetrating network hydrogel is soaked in a bivalent or trivalent cation solution, and the ion-covalent double-network hydrogel is obtained through physical crosslinking. The obtained ion-covalent double-network hydrogel simultaneously has the high deformation and the high intensity and has the good application prospect in the biomedical engineering field.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an ion-covalent double network hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of flexible polymer material with high water content. Water molecules are filled in the three-dimensional porous structure formed by the cross-linking of macromolecular chains. Free water molecules can freely diffuse and flow in the hydrogel network. This characteristic gives Hydrogels are very flexible. Compared with other synthetic materials, such as plastic, rubber and fiber, hydrogel has a structure similar to human tissue, so it can be widely used in the field of biomedical materials. [0003] Human articular cartilage is a high-strength hydrogel with a water content of up to 70wt%, which can reduce friction between adjacent bones and buffer external impacts. Articular cartilage can withstand an external load of nearly 10MPa, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075C08L51/02C08F251/02C08F220/56C08F222/38
CPCC08F251/02C08J3/075C08J3/245C08J2351/02C08F220/56C08F222/385
Inventor 曹晓东吴水平朱杰华李庆涛
Owner SOUTH CHINA UNIV OF TECH
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