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Production technology of salicylic acid

A production process, the technology of salicylic acid, which is applied in the field of medicine and chemical industry, can solve the problems of high temperature in the operating area, taking a long time to cool down, and unsatisfactory cooling effect, so as to increase production capacity, improve economic and social benefits, and reduce temperature Effect

Inactive Publication Date: 2016-03-23
SHANDONG XINHUA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially sodium salicylate refined liquid is in neutralization acid analysis process, adopts large-scale reaction tank (50M usually) because of batch reason 3 ), a large amount of neutralization heat energy is generated during the neutralization process, although the circulating water is used to cool down during the neutralization and acid precipitation process, because the reaction tank is very large, the cooling effect is not ideal, and it takes a long time to cool down, resulting in neutralization and acid precipitation The temperature in the tank operation area is very high; at the same time, the salicylic acid slurry is easily oxidized when it is exposed to the air for a long time; in order to shorten the process time, improve the operating environment for workers, and improve product quality, it is urgent to solve the process of sodium salicylate neutralization and acid precipitation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 6000kg of sodium salicylate aqueous solution into the refining tank, open the drinking water valve, add water to make the mass fraction of sodium salicylate 36%, add sulfuric acid dropwise to make the pH of the solution 5.5; heat up to 60°C, add activated carbon 80kg, decolorized for 45 minutes, and set aside; add water to the sulfuric acid preparation tank, then add concentrated sulfuric acid dropwise, so that the concentration of dilute sulfuric acid is 18%;

[0019] The mass ratio of sodium salicylate solution: dilute sulfuric acid: centrifugal washing water is 2.5:1:2.

[0020] Turn on the sodium salicylate decolorization liquid material transfer pump, open the dilute sulfuric acid feed valve, turn on the centrifugal washing water transfer pump, enter the continuous neutralization reactor through the rotameter, and carry out the neutralization reaction under the condition of stirring and circulating water cooling. Sodium salicylate decolorizing liquid flow is co...

Embodiment 2

[0022] Put 6000kg of sodium salicylate aqueous solution into the refining tank, open the drinking water valve, add water to make the mass fraction of sodium salicylate 38%, add sulfuric acid dropwise to make the pH of the solution 5.7; heat up to 65°C, add activated carbon 90kg, decolorized for 40min to obtain sodium salicylate decolorized solution for subsequent use; add water in the sulfuric acid preparation tank, then add concentrated sulfuric acid dropwise, so that the concentration of dilute sulfuric acid is 20%;

[0023] Wherein, the mass ratio of sodium salicylate solution:dilute sulfuric acid:centrifugal washing water is 2.2:1.2:2.5.

[0024] Turn on the sodium salicylate decolorization liquid material transfer pump, open the dilute sulfuric acid feed valve, turn on the centrifugal washing water transfer pump, enter the continuous neutralization reactor through the rotameter, and carry out the neutralization reaction under the condition of stirring and circulating water...

Embodiment 3

[0026] Put 6000kg of sodium salicylate aqueous solution into the refining tank, open the drinking water valve, add water to make the mass fraction of sodium salicylate 40%, add sulfuric acid dropwise to make the pH of the solution 5.9; heat up to 70°C, add activated carbon 100kg, decolorize for 30 minutes, and set aside; add water to the sulfuric acid preparation tank, then add concentrated sulfuric acid dropwise, so that the concentration of dilute sulfuric acid is 22%;

[0027] Wherein, the mass ratio of sodium salicylate solution: dilute sulfuric acid: centrifugal washing water is 2.5:1.0:3.

[0028] Turn on the sodium salicylate decolorization liquid material transfer pump, open the dilute sulfuric acid feed valve, turn on the centrifugal washing water transfer pump, enter the continuous neutralization reactor through the rotameter, and carry out the neutralization reaction under the condition of stirring and circulating water cooling. Sodium salicylate decolorizing soluti...

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Abstract

The invention relates to a production technology of salicylic acid. When the salicylic acid is neutralized, the mass ratio of a sodium salicylate dilute sulphuric acid: salicylic acid washing water is (2-2.5):(1-1.3):(2-3). This production technology is simple, the use amount of cooling water is greatly decreased, and the cost is saved; the process time is shortened, and the productivity is improved without device addition; meanwhile the temperature of a reactor material outlet is reduced, the production technology is environmentally friendly and is chemically green, and the economic and social benefits are effectively improved.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, in particular to a production process of salicylic acid. Background technique [0002] Salicylic acid has a wide range of uses and is currently an extremely important pharmaceutical and chemical raw material. It is mainly used to manufacture antipyretic and analgesic drugs aspirin, and it is also a variety of important drugs such as methyl salicylate, ethyl salicylate and salicylamide. Synthetic raw materials are produced. The domestic market size of salicylic acid alone is about 20,000 tons. my country is the main producer and exporter of salicylic acid derivatives such as aspirin and methyl salicylate in the world. Therefore, the use of salicylic acid is huge, so the development A process with short process time, simple operation and environmental friendliness is very necessary. [0003] The traditional process uses phenol to react with sodium hydroxide to produce phenol sodium sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/02C07C65/10
CPCC07C51/02
Inventor 吴孝好何雪涛陈洪全房民张玲
Owner SHANDONG XINHUA PHARMA CO LTD
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