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Bone cement containing calcium citrate and its preparation method

A technology of calcium citrate and bone cement, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of low similarity, low degradation rate, and limited clinical application, and achieve a wide range of applications and improved anti-collapse ability , good plasticity effect

Active Publication Date: 2018-08-31
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a single calcium citrate degrades quickly and is not very similar to natural bone, and its clinical application is limited only in the form of compressed tablets; a single HA or TTCP / DCPA is brittle and has a low degradation rate, and its osteoinductive effect is not significant , so it is difficult for a single material to meet the requirements of bone cement in the field of bone repair, so it will be of great application value to use materials with different properties to combine to obtain a composite bone cement material with new properties

Method used

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  • Bone cement containing calcium citrate and its preparation method
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preparation example Construction

[0042] The present invention also provides a preparation method of calcium citrate and calcium phosphate multi-component composite bone cement, the specific steps of which are as follows:

[0043] (1) Preparation of micron-scale spherical, nano-sheet and nano-fibrous calcium citrate: respectively according to Chinese patent application CN201410612039.9 "Spherical calcium citrate and its preparation method and application", Chinese patent application CN201410061265.2 "Nano citric acid "Preparation method of calcium" and Chinese application patent CN201410612150.8 "fibrous calcium citrate and its preparation method and application" to prepare spherical, flake and fibrous calcium citrate as the powder phase of bone cement for future use .

[0044] (2) Preparation of HA: According to the literature "Preparation and Characterization of Nano-Hydroxyapatite" (Wang Yuming, Liu Zhihui, Cheng Fengmei, etc. Preparation and Characterization of Nano-Hydroxyapatite [J]. Chemical Science and...

Embodiment 1

[0050] Weigh 0.5mol of KH 2 PO 4 and 0.5 mol of K 2 HPO 4 ·3H 2 O was added to 50ml of deionized water, stirred with a glass rod to dissolve it completely, and then the mixed solution was transferred to a 100ml volumetric flask to constant volume to obtain 0.5mol / L aqueous solution of potassium dihydrogen phosphate and dipotassium hydrogen phosphate, which was recorded as solidified Solution A; put the prepared solidification solution in a 4°C refrigerator for later use.

[0051] Prepare Example 1 according to the formula in Table 1, the preparation method is: uniformly mix calcium citrate and HA in a small mortar with a mass ratio of 3:1, and then accurately measure the solidified liquid according to the liquid-solid ratio of 1:1 A. Add the solidification liquid to the solid phase powder, stir quickly and evenly, and then fill it into a mold with a length, width, and height of 1 cm for solidification and molding. (Note: When the calcium citrate used is commercially avail...

Embodiment 2

[0055] Prepare Example 2 according to the formula in Table 2, and its preparation method is: uniformly mix nanoscale flaky calcium citrate and HA in a small mortar with a mass ratio of 3:1, and then accurately press the liquid-solid ratio in Table 2 Measure the solidification solution A, add the solidification solution to the solid phase powder, stir quickly and evenly, then fill it into a mold with a length, width and height of 1cm and solidify it.

[0056] Table 2

[0057] serial number

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Abstract

The invention belongs to the field of bone damage repair medicinal materials and particularly relates to a preparation method and application of bone cement containing calcium citrate. The bone cement containing calcium citrate is composed of a solid phase part and a liquid phase part, the solid phase part is formed by compounding the calcium citrate and calcium phosphate salt, and the mass ratio of the calcium citrate to the calcium phosphate salt is (2-5):1; the liquid-solid ratio is (0.5-1.5):1. The bone cement containing the calcium citrate has comprehensive biomedical properties such as good plasticity, bone guidance, bone induction activity, cell activity and good degradation rate and is applicable to the orthopedics department, the thoracic surgery department and shaping and restoration of skull and jaw surfaces.

Description

technical field [0001] The invention belongs to the field of medical materials for bone injury repair, and in particular relates to a preparation method and application of calcium citrate-containing bone cement. Background technique [0002] Various traumas and chronic diseases such as osteoporosis have significantly increased the incidence of fractures and bone defects. How to make fractures and bone defects heal better and faster has become one of the hot issues studied by orthopedic surgeons. Calcium is one of the main minerals in bone tissue. 99% of the calcium in the human body exists in the bone, and only 1% circulates in the extracellular fluid. The calcium deposited in the callus in the early stage of fracture mainly comes from the bone tissue rather than diet Intake, in the late stage of fracture healing, dietary calcium becomes the main source. Therefore, it is necessary to fill bone graft biomaterials in the early healing of fractures and bone defects, and release...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/50
CPCA61L27/12A61L27/50A61L2430/02
Inventor 李峻峰刘雨晴高阳赵瑞兰邹琴曹文强钟良兆赖雪飞
Owner CHENGDU UNIVERSITY OF TECHNOLOGY
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