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Drug composition containing loxoprofen sodium and preparation method of drug composition

A technology of loxoprofen sodium and its composition, which is applied in the field of loxoprofen sodium-containing pharmaceutical composition and its preparation, and can solve the problems of difficult mixing uniformity, unfavorable application, poor mutual binding force between the drug layer and the base layer, etc. , achieve the effects of shortening the production cycle, reducing energy consumption, and shortening the drug preparation time

Inactive Publication Date: 2016-03-09
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing preparation method, it takes a long time to dissolve the selected skeleton material with cyclohexane, and it is not easy to mix uniformly; the existing patch has a three-layer structure, which is specifically a backing layer, a drug layer and a base layer, and the drug layer and The mutual binding force of the base layer is poor, which is not conducive to application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A pharmaceutical composition containing loxoprofen sodium, the dosage form of the pharmaceutical composition is a patch, and the patch is successively composed of an anti-adhesive film, a drug layer coated on the anti-adhesive film, and coated on the anti-adhesive film. The base layer on the drug layer is composed of a medical elastic cloth of 180cm×2000cm, and the thickness of the drug layer is 35 μm. The drug layer is prepared from the following components: 50 g of loxoprofen sodium, 70 g of polyacrylic acid resin IV, 200 g of pressure-sensitive adhesive, 10 g of azone, 30 g of propylene glycol, and 60 g of absolute ethanol.

Embodiment 2

[0034] A pharmaceutical composition containing loxoprofen sodium, the dosage form of the pharmaceutical composition is a patch, and the patch is successively composed of an anti-adhesive film, a drug layer coated on the anti-adhesive film, and coated on the anti-adhesive film. The base layer on the drug layer is composed of a medical elastic cloth of 180cm×2000cm, and the thickness of the drug layer is 35 μm. The drug layer is prepared from the following components: 50 g of loxoprofen sodium, 87.5 g of polyacrylic acid resin IV, 248.5 g of pressure-sensitive adhesive, 15 g of azone, 45 g of propylene glycol, and 80 g of absolute ethanol.

Embodiment 3

[0036] A pharmaceutical composition containing loxoprofen sodium, the dosage form of the pharmaceutical composition is a patch, and the patch is successively composed of an anti-adhesive film, a drug layer coated on the anti-adhesive film, and coated on the anti-adhesive film. The base layer on the drug layer is composed of a medical elastic cloth of 180cm×2000cm, and the thickness of the drug layer is 65 μm. The drug layer is prepared from the following components: 50 g of loxoprofen sodium, 95 g of polyacrylic resin IV, 350 g of pressure-sensitive adhesive, 25 g of azone, 60 g of propylene glycol, and 110 g of absolute ethanol.

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Abstract

The invention relates to a drug composition containing loxoprofen sodium and a preparation method of the drug composition. A loxoprofen sodium patch is successively formed by an antisticking film, a drug layer smeared on the antisticking film and a substrate layer covering the drug layer; and the drug layer is prepared from the following components: loxoprofen sodium, a skeleton material, an adhesive, a transdermal enhancers a skeleton material solvent, and the weight ratio of the loxoprofen sodium to the skeleton material is 1 to (1 to 2). When the drug layer is prepared, adhesive cement is homogenized by adopting a homogenizing machine, so that various components are more uniformly dispersed, the uniformity of the drug release speed is guaranteed, and the curative effect is relatively good.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing loxoprofen sodium and a preparation method thereof. Background technique [0002] Loxoprofen sodium is the first phenylpropionic acid non-steroidal antipyretic analgesic. Loxoprofen sodium is a non-steroidal antipyretic, analgesic, and anti-inflammatory drug developed by Daiichi Sankyo Co., Ltd. for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, and osteoarthritis , low back pain, frozen shoulder, neck and wrist syndrome, and swelling and pain after surgery, trauma and tooth extraction. [0003] Loxoprofen sodium is absorbed rapidly after oral administration, and is distributed in the liver, kidney, and plasma at a higher concentration; thereafter, most of it is the glucuronic acid conjugate of the original substance or the glucuronic acid conjugate of the hydroxylated substance, mainly through Urinary excre...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61K47/32A61K47/10A61K47/22A61P29/00
CPCA61K9/7038A61K31/192A61K47/10A61K47/22A61K47/32
Inventor 杜明松
Owner 蚌埠丰原涂山制药有限公司
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