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A composition for treating dry socket and its preparation method

A composition and dry socket technology, applied in the field of oral care, can solve the problems of being unusable, having no antibacterial effect, and being unable to prevent wound tissue infection, etc., achieving the effect of preventing bacterial infection, good hemostasis effect, and convenient clinical application

Active Publication Date: 2018-12-04
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this dressing is only used as a general medical sponge, which does not have antibacterial effect and cannot prevent wound tissue infection, so it cannot be used for the treatment of dry socket

Method used

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  • A composition for treating dry socket and its preparation method
  • A composition for treating dry socket and its preparation method
  • A composition for treating dry socket and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Dissolution of PVA: Dissolve PVA in a container, the mass ratio of PVA to distilled water is 1:7. The PVA can be completely dissolved by dissolving for 20 minutes at a temperature of 70°C and a stirring speed of 350r / min.

[0057] 2. Acetalization: take 30g of completely dissolved PVA, add 4.5g of starch, stir evenly at room temperature (rotational speed is about 400r / min), then add 5.0mL of formaldehyde, 1.5mL of pentane, 5.0mL of sulfuric acid, and continue to stir for 5min , immediately put into the oven for curing for 1h after completion (the oven temperature is constant at 40°C). The solidified obtained sponge washes away the starch of the pore filling agent with clear water to obtain a medical sponge.

[0058] 3. Take 0.1g of sodium hyaluronate and add 10mL of distilled water to prepare sodium hyaluronate gel.

[0059] 4. Take 0.1g of bioactive mineral powder, add it to sodium hyaluronate gel, and stir evenly. Take 0.2g of the medical sponge prepared in step...

Embodiment 2

[0062] 1. Dissolution of PVA: Dissolve PVA in a container, the mass ratio of PVA to distilled water is 1:7. The PVA can be completely dissolved by dissolving for 20 minutes at a temperature of 70°C and a stirring speed of 350r / min.

[0063] 2. Acetalization: take 30g of completely dissolved PVA, add 4.5g of starch, stir evenly at room temperature (rotational speed is about 400r / min), then add 5.0mL of formaldehyde, 1.5mL of pentane, 5.0mL of sulfuric acid, and continue to stir for 5min , immediately put into the oven for curing for 1h after completion (the oven temperature is constant at 40°C). The solidified obtained sponge washes away the starch of the pore filling agent with clear water to obtain a medical sponge.

[0064] 3. Take 0.1g of sodium hyaluronate and add 10mL of distilled water to prepare sodium hyaluronate gel.

[0065] 4. Take 0.2g of bioactive mineral powder, add it to sodium hyaluronate gel, and stir evenly. Take 0.25g of the medical sponge prepared in ste...

Embodiment 3

[0068] 1. Dissolution of PVA: Dissolve PVA in a container, the mass ratio of PVA to distilled water is 1:7. The PVA can be completely dissolved by dissolving for 20 minutes at a temperature of 70°C and a stirring speed of 350r / min.

[0069] 2. Acetalization: Take 30g of completely dissolved PVA, add 4.5g of starch, stir evenly at room temperature (rotational speed is about 400r / min), then add 5.0mL formaldehyde, 1.5mL pentane, 5.0mL sulfuric acid in sequence, and continue stirring for 5min , immediately put into the oven for curing for 1h after completion (the oven temperature is constant at 40°C). The solidified obtained sponge washes away the starch of the pore filling agent with clear water to obtain a medical sponge.

[0070] 3. Take 0.1g of sodium hyaluronate and add 10mL of distilled water to prepare sodium hyaluronate gel.

[0071] 4. Take 0.15g of bioactive mineral powder, add it to sodium hyaluronate gel, and stir evenly. Take 0.15g of the medical sponge prepared i...

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Abstract

The invention provides a composition for treating dry socket. The composition is prepared from the following raw materials in parts by weight: 5-25 parts of standard nanoscale bioactive mineral substance powder, 10 parts of an absorbable biopolymer material, and 8-30 parts of medical sponge, wherein the absorbable biopolymer material is selected from one or more of sodium hyaluronate, a water soluble chitosan derivative, alginate and gelatin; the bioactive mineral substance powder contains the following components in percentage by weight: 45-61% of SiO2, 17-27% of CaO, 19-25% of Na2O, and 2.6-6% of P2O5, wherein the particle size range of the bioactive mineral substance powder is small than 90 um, and the bioactive mineral substance powder contains 0.1-20.0 wt% of the standard nanoscale particles with the pore diameters being 100-900 nm.

Description

technical field [0001] The invention relates to the field of oral care, in particular to a composition for treating dry socket and a preparation method thereof. Background technique [0002] Tooth extraction is the most common clinical operation in alveolar surgery, and the most common causes of tooth extraction are dental caries and periodontitis. The last molar of the mandible is impacted, often covered by gingiva, forming a deep pocket between the gingiva and the crown surface, which is easy to store bacteria and food, causing pericoronitis, and repeated attacks. In order to eradicate its pain, it often needs to be treated with inflammation Tooth extraction after subside. In addition, with the improvement of living standards, people require teeth to be neat and beautiful. Extracting one or two premolars for subtractive extraction is one of the common methods for correcting the misalignment of the upper anterior dentition. [0003] A tooth extraction wound is a wound for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/06A61L24/02
CPCA61L24/001A61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/06A61L24/08A61L24/104A61L2300/404A61L2300/452A61L2300/602A61L2400/04A61L2400/12C08L29/04C08L5/08
Inventor 李湘杰李伟峰翟晖李次会丁力
Owner BEIJING DATSING BIO TECH
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