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Preparation method for salinomycin granular preparation

A granular preparation, salinomycin technology, applied in the field of medicine, can solve the problems of low spray efficiency and low yield, and achieve the effect of improving efficiency, overcoming low yield, and shortening the time of stratification

Inactive Publication Date: 2016-02-17
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a preparation method of salinomycin granule preparation to overcome the problems of low yield and low spray efficiency caused by the existing salinomycin granule preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation method of salinomycin granule preparation comprises the following steps:

[0020] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 80,000u / ml to 4.0 with sulfuric acid;

[0021] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 60°C for 3 hours;

[0022] 3) Preparation of salinomycin feed liquid: adding a certain amount of calcium carbonate to the acidic fermentation liquid obtained in step 2) to make salinomycin feed liquid, the amount of calcium carbonate added is 10% of the mass of the acidic fermentation liquid;

[0023] 4) Spray drying, adding spray granulation to the salinomycin feed liquid prepared in step 3) and making granules by spray drying method to obtain salinomycin granule preparation; the spray granulation is composed of the following weight components: 50 parts by weight of corn flour, 100 parts by weight of bentonite, ...

Embodiment 2

[0025] The preparation method of salinomycin granule preparation comprises the following steps:

[0026] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 90000u / ml to 4.5 with sulfuric acid;

[0027] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 62°C for 3.5 hours;

[0028] 3) Preparation of salinomycin feed liquid: adding a certain amount of calcium carbonate to the acidic fermentation liquid obtained in step 2) to make salinomycin feed liquid, the amount of calcium carbonate added is 15% of the mass of the acidic fermentation liquid;

[0029] 4) Spray drying, adding spray granulation to the salinomycin feed liquid prepared in step 3) and making granules by spray drying method to obtain salinomycin granule preparation; the spray granulation is composed of the following weight components: 60 parts by weight of corn flour, 120 parts by weight of bentonite,...

Embodiment 3

[0031] The preparation method of salinomycin granule preparation comprises the following steps:

[0032] 1) Preparation of acidic fermentation broth: adjust the pH of the salinomycin fermentation broth with a drug price of 100,000u / ml to 5.0 with sulfuric acid;

[0033] 2) Pretreatment of the acidic fermentation broth: keep the pH-adjusted acidic fermentation broth at 65°C for 4 hours;

[0034] 3) Preparation of salinomycin feed liquid: adding a certain amount of calcium carbonate to the acidic fermentation liquid obtained in step 2) to make salinomycin feed liquid, the amount of calcium carbonate added is 20% of the mass of the acidic fermentation liquid;

[0035] 4) Spray drying, adding spray granulation to the salinomycin feed liquid prepared in step 3) and making granules by spray drying method to obtain salinomycin granule preparation; the spray granulation is composed of the following weight components: 55 parts by weight of corn flour, 110 parts by weight of bentonite,...

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Abstract

The invention relates to a preparation method for a salinomycin granular preparation. The preparation method includes the following steps that acid fermentation liquor is prepared, wherein the pH value of the salinomycin fermentation liquor is adjusted to range from 4.0 to 5.0 through acid liquor; the acid fermentation liquor is pre-treated, wherein the acid fermentation liquor with the adjusted pH value is subjected to heat preservation for 3-4 hours at the temperature of 60 DEG C to 65 DEG C; salinomycin feed liquor is prepared, wherein a certain amount of light calcium carbonate is added to the obtained acid fermentation liquor to prepare the salinomycin feed liquor; spray drying is conducted, wherein the prepared salinomycin feed liquor is prepared into particles through a spray drying method, and then the salinomycin granular preparation is obtained. Acid fermentation is adopted in the salinomycin fermentation process, the layering speed of the fermentation liquor is increased, the layering time is shortened, layering is complete, the yield of salinomycin is increased, the spray pelleting is added and matched with set spraying conditions, spraying efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of salinomycin granule preparation. Background technique [0002] Salinomycin is a polyether ionophore antibiotic produced by Streptomyces albus. Salinomycin granule preparation not only has good antibacterial effect, low toxicity and low residue, simple production process, readily available raw materials and low price, it is one of the most promising veterinary drugs recognized in the market. [0003] Salinomycin has a strong inhibitory and killing effect on most Gram-positive bacteria and various coccidiosis, and it is not easy to produce drug resistance and cross-resistance. It is excreted quickly and the residual amount is extremely low. It can be used to prevent diarrhea, Promote production and increase survival rate. Salinomycin has a cation transport function in cells, especially for potassium ions, sodium ions, and rubidium ions, but these ions sel...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/7048A61P31/04
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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