Application of vacuolar protein sorting 4A to preparing medicines for preventing or treating enterovirus type 71 infection

Abstract

The invention provides application of vacuolar protein sorting 4A (VPS4A) to preparing medicines for preventing or treating enterovirus type 71 infection, relates to the technical field of biomedicine, and provides novel enterovirus type 71 infection resisting targets and application. The application includes that expression of host proteins of target cells which are human colon cancer cells (Caco-2) is down-regulated by the aid of an RNA (ribonucleic acid) interference technology, so that host factors capable of effectively inhibiting EV71 (enterovirus type 71)-infected human colon cancer cells (Caco-2) can be searched, and the purpose of effectively eliminating EV71 infection from sources (intestinal tracts) can be achieved. The application has the advantages that as discovered via experiments, important effects can be realized by the vacuolar protein sorting 4homolog A (VPS4A) for the EV71-infected Caco-2, expression of the VPS4A is down-regulated, and accordingly EV71 infection can be obviously inhibited.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and is a new target and application for resisting enterovirus 71 infection. Background technique [0002] Enterovirus 71 (enterovirus71, EV71) belongs to the Picornaviridae Enterovirus genus Human Enterovirus A, and is one of the main pathogens that cause Hand-foot-mouth disease (HFMD). Currently, hand, foot and mouth disease is breaking out and spreading in many parts of the world, especially in the Asia-Pacific region. In my country, since the outbreak of hand, foot and mouth disease in several major provinces and cities in 2008, the number of people infected and the death rate of the disease have remained high, with more than 1 million cases and nearly 1,000 deaths reported every year. The main patients with HFMD are infants and young children under 5 years old. The clinical manifestations are fever, herpes and other symptoms in the hands, feet, buttocks and oral mucosa; a small number of...

AI Technical Summary

Problems solved by technology

[0009] At present, there are no reports on the role of VPS4A and HRS molecules in EV71-infected host cells (especially Caco-2 cells). In-depth research on these two molecules will not only improve the understanding of EV71 infection and pathogenic mechanisms, but also Provide new ideas and targets for the prevention and treatment of EV71 infection

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