Application of a drug combination as a drug for the preparation of drugs for the treatment of neuropsychiatric disorders and skin diseases

A technology for neuropsychiatric disorder and composition, which is applied in the field of medicine and achieves the effect of low toxicity and side effects

Active Publication Date: 2019-02-26
施惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the steroid-like effect of glycyrrhizic acid, long-term oral administration of active ingredient extracts of licorice or glycyrrhizic acid and its derivatives will cause patients to have serious adverse reactions such as water and sodium retention, high blood pressure and hypokalemia.

Method used

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  • Application of a drug combination as a drug for the preparation of drugs for the treatment of neuropsychiatric disorders and skin diseases
  • Application of a drug combination as a drug for the preparation of drugs for the treatment of neuropsychiatric disorders and skin diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Comparison of acute toxic effects of oxymatrine, glycyrrhizic acid and their compositions on mice

[0023] Kunming mice were randomly divided into a normal control group and a test drug group, with ten mice in each group, half male and half male. In addition to the normal control group, the test drug group was injected intraperitoneally (ip) with a large dose of oxymatrine, glycyrrhizin and the combination of the two components once, and the animals were observed continuously for 7 days, and the death time and number of animals were recorded.

[0024] The results showed that when the dose of oxymatrine was 950mg / kg, it had great toxicity, and 9 of the 10 mice died; when the dose of glycyrrhizin was 950mg / kg, 2 of the 10 mice died, while the oxidized Kushen minus: glycyrrhizin ratio 1:1 and combined dose of 950mg / kg and matrine: glycyrrhizin ratio of 2:1 and combined dosage of 950mg / kg, no animals died, oxidized matrine reduced: glycyrrhizin When the ratio of oxymatrine...

Embodiment 2

[0029] Observation on the curative effect of compound glycyrrhizin combined with oxymatrine in the treatment of chronic lichen simplex

[0030] 1 Materials and methods

[0031] 1.1 Clinical data 40 patients who were clinically diagnosed with generalized lichen simplex chronica, 20 males and 20 females, aged 23 to 55 years, had not received treatment within one month, and had no serious visceral diseases such as liver and kidney dysfunction. No history of active tuberculosis, hypertension, diabetes, cataract, pregnant and lactating women were excluded. The patients were randomly divided into four groups: oxymatrine treatment group (group A), compound glycyrrhizin treatment group (group B), oxymatrine combined with compound glycyrrhizin treatment group (group C), and control group (group D). group), ten cases in each group, half male and half male. There was no statistical difference among the four groups in terms of age, gender, and disease severity (P>0.05).

[0032] 1.2 Tr...

Embodiment 3

[0043] Clinical observation of compound glycyrrhizin combined with oxymatrine in the treatment of prurigo nodularis

[0044] 1 Materials and methods

[0045] 1.1 Clinical data The clinical diagnosis of 40 patients with prurigo nodularis, 20 males and 20 females, aged 35-51 years, had not received any treatment within one month, no serious visceral diseases such as liver and kidney damage, no activity Tuberculosis, hypertension, diabetes, cataract medical history, excluding pregnant and lactating women. The patients were randomly divided into four groups: oxymatrine treatment group (group A), compound glycyrrhizin treatment group (group B), oxymatrine combined with compound glycyrrhizin treatment group (group C), and control group (group D). group), ten cases in each group, half male and half male. There was no statistical difference among the four groups in terms of age, gender, and disease severity (P>0.05).

[0046] 1.2 Treatment method Group A was given intravenous infus...

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PUM

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Abstract

The invention relates to kushenin (oxymatrine, matrine and isomatrine) and glycyrrhizic acid or their pharmaceutically acceptable forms or derivatives and a kit containing the compositions, and also relates to matrine glycyrrhizate and kushenin glycyrrhizate. The invention discloses an application of the compositions in preparation of drugs for preventing and treating neuropsychic disturbance dermatosis (pruritus, lichen simplex chronicus, prurigo, nodular prurigo, prurigo pigmentosa and lichenoid dermatitis).

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of a pharmaceutical composition in the preparation of prevention and treatment of neuropsychiatric skin diseases. The pharmaceutical composition contains matrine (oxymatrine, matrine, isomatrine) and glycyrrhizic acid or a pharmaceutically acceptable form of the two or derivatives of the two and the composition containing these The medicine box also includes glycyrrhizic acid matrine salt and glycyrrhizic acid matrine salt. Background technique [0002] There are many types of skin diseases related to skin and nervous system, and their classification has not yet been unified. The neuropsychiatric skin diseases described in the present invention are mainly common related diseases, including pruritus, lichen simplex chronica, prurigo, prurigo nodularis, prurigo pigmentosa and lichenoid dermatitis. Pruritus is clinically defined as a skin disease characterized by pruritus with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P17/00A61P17/04A61P25/18A61K31/4375
Inventor 施惠娟
Owner 施惠娟
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