Biological ink for 3D printing

Abstract

The invention discloses biological ink for 3D printing. The biological ink for 3D printing comprises water-soluble synthetic polymer with the cross-linking function, water-soluble natural polymer with the cross-linking function, bioactive components capable of spontaneously forming special ultrastructures, cross-linking initiator and solvents and further comprises bioactive components. The biological ink for 3D printing overcomes the defects that traditional 3d printing ink is single in component structure, does not have good biological activity and needs to utilize organic solvents, and it is difficult to take cell compatibility, biological activity and mechanical properties into consideration, the biological ink which has biological activity and the fast curing function at the same time and can form a certain microstructure is obtained, and hydrogel obtained through curing of the ink has controllable mechanical properties, good structural stability and a good fidelity effect.

Description

technical field [0001] The invention relates to an ink, in particular to a bio-ink used for 3D bio-printing to manufacture bio-scaffold materials such as bio-tissues and organs. Background technique [0002] 3D printing technology (also known as 3D rapid prototyping technology or additive manufacturing technology) is an emerging manufacturing technology that has emerged in recent years. This technology is mainly under computer control, according to the computer-aided design (CAD) model or computer tomography of the printed object Scanning (CT) is a digital molding technology that quickly manufactures 3D objects of a specified shape through the accurate 3D accumulation of materials and the converted model after the data is obtained. With the continuous advancement of 3D printing technology, its application fields include daily necessities, mechanical equipment, biomedicine, etc. Although 3D printing technology has attracted enough attention in the fields of biomedicine, such...

AI Technical Summary

Problems solved by technology

Although 3D printing technology has attracted enough attention in the fields of biomedicine, such as disease models, drug sustained release, tissue engineering and regenerative medicine, so far, the use of 3D printing technology to manufacture organs or tissues that are truly suitable for implantation in the body still faces great challenges. challenges, of which developing biomaterials suitable for 3D printing is key

Most of the above-mentioned synthetic materials are 3D printed with organic solvents or high temperature. The printed scaffold structure is stable, but the accuracy is limited, and it cannot be mixed with cells for printing.

Water-soluble natural polymer materials can be printed simultaneously with cells and maintain their activity, but the mechanical properties, simulation and stability of the scaffold are poor

Existing materials are difficult to balance cell compatibility, bioactivity and mechanical properties whether used alone or in combination

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