Collagen polypeptide nanosphere surface positive charge modification method

A technology of collagen polypeptide and modification method, which is applied in the field of tanning waste-collagen reuse, can solve the problems of difficult treatment of chemical sludge, affecting the separation and recovery of uranium, and high chemical toxicity, achieving good application prospects, easy promotion, The effect of simple production process

Inactive Publication Date: 2016-01-13
SOUTHWEAT UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Wastewater generated during the wet uranium production process contains relatively high concentrations of fluorine (F - ), which has high chemical toxicity and strong corrosiveness, has a strong corrosive effect on separation carriers such as ion exchange resins, and seriously affects uranium (uranyl ion UO 2 2+ ) separation and recovery
At present, precipitation method and adsorption method are considered to be the common methods to remove fluorine in water. The precipitation method has the advantages of simple operation and low cost, but the chemical sludge is difficult to deal with and has many defects.

Method used

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  • Collagen polypeptide nanosphere surface positive charge modification method

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Experimental program
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Effect test

Embodiment 1

[0030] Step 1. Disperse 10.0 mg of collagen peptide nanospheres in 150 mL of distilled water, and add 0.5 mg of Al while stirring 2 (SO 4 ) 3 , stirred the reaction for 2 hours, and then used 1mol.L -1 NaHCO 3 The pH value of the solution was adjusted to 4.5, and the stirring reaction was continued for 30 minutes, centrifuged and separated to obtain Al 3+ Modified collagen peptide nanospheres;

[0031] Step two, take 10mgAl 3+ The modified collagen polypeptide nanospheres were dispersed in 150mL of distilled water, and 1mg of dodecyltrimethylammonium chloride was added while stirring, and 1mol.L -1 Adjust the pH value of the system to 5 with HCl, protect it with nitrogen (purity ≥ 99.99%), add 0.3 mg of azobisisobutyronitrile, stir and react in a water bath at 25°C for 7 hours, centrifuge, separate, and freeze-dry to obtain positively charged surface-modified collagen Peptide Nanospheres.

Embodiment 2

[0033] Step 1. Disperse 10.0 mg of collagen peptide nanospheres in 150 mL of distilled water, and add 0.3 mg of Al while stirring 2 (SO 4 ) 3 , stirred the reaction for 3 hours, and then used 1mol.L -1 NaHCO 3 The pH value of the solution was adjusted to 4.5, and the stirring reaction was continued for 30 minutes, centrifuged and separated to obtain Al 3+ Modified collagen peptide nanospheres;

[0034] Step two, take 10mgAl 3+ The modified collagen polypeptide nanospheres were dispersed in 150mL of distilled water, and 1mg of methacryloyloxyethyltrimethylammonium chloride was added while stirring, and mixed with 1mol.L -1 Adjust the pH value of the system to 5 with HCl, pass nitrogen (purity ≥ 99.99%) for protection, add 0.3 mg of dibenzoyl peroxide, stir and react in a water bath at 25 ° C for 7 hours, centrifuge, separate, and freeze-dry to obtain positively charged surface-modified collagen Peptide Nanospheres.

Embodiment 3

[0036] Step 1. Disperse 10.0 mg of collagen peptide nanospheres in 150 mL of distilled water, and add 0.3 mg of Al while stirring 2 (SO 4 ) 3 , stirred the reaction for 3 hours, and then used 1mol.L -1NaHCO 3 The pH value of the solution was adjusted to 4.5, and the stirring reaction was continued for 30 minutes, centrifuged and separated to obtain Al 3+ Modified collagen peptide nanospheres;

[0037] Step two, take 10mgAl 3+ The modified collagen polypeptide nanospheres were dispersed in 150mL of distilled water, and 1.5mg of dodecyldimethylbenzyl ammonium chloride was added while stirring, and mixed with 1mol.L -1 Adjust the pH value of the system to 5 with HCl, pass nitrogen (purity ≥ 99.99%) for protection, add 0.5 mg of ammonium persulfate, stir and react in a water bath at 25°C for 10 hours, centrifuge, separate, and freeze-dry to obtain positively charged surface-modified collagen polypeptide nanospheres .

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Abstract

The invention discloses a collagen polypeptide nanosphere surface positive charge modification method. The method includes: dispersing collagen polypeptide nanospheres in distilled water, adding Al2(SO4)3 under stirring, carrying out stirring reaction, then regulating the pH value of the system to 3.5-5.0, further carrying out stirring reaction, and performing centrifugation and separation to obtain Al<3+> modified collagen polypeptide nanosphere; dispersing the Al<3+> modified collagen polypeptide nanosphere in distilled water, adding a strong positive charge material under stirring, adjusting the pH value of the system to 4-7, introducing nitrogen for protection, adding an initiator, carrying out stirring reaction, centrifugation, separation, and freezing drying, thus obtaining the positive charge surface modified collagen polypeptide nanosphere. According to the aluminum tanning principle in a tanning chemical process, cations with good binding capacity with fluorine ions are introduced through reaction of Al<3+> and collagen polypeptide nanospheres, also the strong electropositive compound is further introduced through Michael addition reaction, and the excellent performance of nanoparticles is combined so as to effectively adsorb and separate fluorinions in wastewater.

Description

technical field [0001] The invention relates to a method for modifying the positive charge on the surface of collagen polypeptide nanospheres, and belongs to the technical field of tanning waste-collagen reuse. Background technique [0002] Wastewater generated during the wet uranium production process contains relatively high concentrations of fluorine (F - ), which has high chemical toxicity and strong corrosiveness, has a strong corrosive effect on separation carriers such as ion exchange resins, and seriously affects uranium (uranyl ion UO 2 2+ ) for separation and recovery. At present, precipitation and adsorption are considered to be the common methods to remove fluorine in water. The precipitation method has the advantages of simple operation and low cost, but the chemical sludge is difficult to deal with and has many defects. The commonly used adsorption method is an effective method to treat low-concentration fluorine-containing wastewater. Commonly used adsorben...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J20/26B01J20/30C07K14/78C07K1/12
Inventor 周建苏林竹文坤张红平罗学刚
Owner SOUTHWEAT UNIV OF SCI & TECH
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