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A taste-masking orally disintegrating preparation of flunixin meglumine and its preparation method

A flunixin meglumine and orally disintegrating technology, which is applied in anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., can solve the problems that there are no reports of flunixin meglumine orally disintegrating tablets, and achieve advanced technology , less drug loss and lower cost

Active Publication Date: 2019-03-15
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In veterinary clinics, there have been reports on the successful development of veterinary orally disintegrating tablets, but there is no related report on flunixin meglumine orally disintegrating tablets

Method used

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  • A taste-masking orally disintegrating preparation of flunixin meglumine and its preparation method
  • A taste-masking orally disintegrating preparation of flunixin meglumine and its preparation method
  • A taste-masking orally disintegrating preparation of flunixin meglumine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The first step is to take the raw materials flunixin meglumine and Eudragit EPO respectively, crush them, pass through an 80-mesh sieve, and mix them uniformly in a ratio of 1:2 according to the equal-volume incremental dilution method to prepare a physical mixture; the diameter of the screw is 16-24mm A twin-screw extruder, the twin-screw extruder is set to be a screw element of a single mixing kneading block (such as figure 1 The screw structure shown in 3), the melt extrusion temperature of the extruder is 140 °C, after the temperature rises to the set value, the screw speed is set to 100rpm / min, after the speed is stable, add the physical mixture, and pass through the extruder Melting, shearing, and conveying to obtain a yellow transparent strip extrudate; after the extrudate is cooled, it is crushed and sieved, and the sieve of 30 to 50 meshes is retained to obtain a taste-masked solid dispersion of flunixin meglumine body.

[0035] In the second step, the ingredi...

Embodiment 2

[0037] The first step is to take the raw materials of flunixin meglumine, Eudragit EPO, Kollicoat Smartseal30D, and ethyl cellulose respectively, grind them, pass through a 90-mesh sieve, and mix them uniformly in the ratio of 1:2:1:1 by the method of equal incremental dilution , prepared into a physical mixture; select a twin-screw extruder with a screw diameter of 16 to 24 mm, and set the twin-screw extrusion element as a single-mixing kneading screw element (such as figure 1 The screw structure shown in 3), the melt extrusion temperature of the extruder is 155 °C, after the temperature rises to the set value, the screw speed is set to 150rpm / min, and the physical mixture is added after the speed is stable, and the extruder Melting, shearing, and conveying to obtain a yellow transparent strip-shaped extrudate; after the extrudate is cooled, it is crushed and sieved, and the sieved material of 40 to 50 meshes is retained to obtain a taste-masked solid dispersion of flunixin me...

Embodiment 3

[0040] The first step is to take the raw materials flunixin meglumine and acrylic resin IV respectively, crush them, pass through a 60-mesh sieve, and mix them uniformly in the ratio of 1:4 by equal incremental dilution method to prepare a physical mixture; choose a screw with a diameter of 16~ 24mm twin-screw extruder, set the twin-screw extrusion element as a screw element of a single mixing kneading block (such as figure 1 The screw structure shown in 3), the melt extrusion temperature of the extruder is 135°C, after the temperature rises to the set value, set the screw speed to 80rpm / min, add the physical mixture after the speed stabilizes, and pass through the extruder Melting, shearing, and conveying to obtain a yellow transparent strip-like extrudate; after the extrudate is cooled, it is crushed and sieved, and the sieve of 35 to 50 meshes is retained to obtain a taste-masked solid dispersion of flunixin meglumine body.

[0041] In the second step, mix the ingredients ...

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Abstract

The invention discloses a flunixin meglumine taste masking orally-disintegrating preparation and a preparing method thereof, and belongs to the technical field of veterinary drugs. The preparing method of the preparation includes the steps that raw-material flunixin meglumine and taste masking agents are mixed in the weight ratio of 1:(2-4) to be subjected to taste masking treatment, taste-masking solid dispersion is made, then the taste-masking solid dispersion and auxiliary materials including water solubility fillers, disintegrating agents, flavoring agents, lubricants and the like are evenly mixed, and the preparation is obtained. Compared with the prior art, the taste masking effect of the flunixin meglumine taste masking orally-disintegrating preparation is achieved with the hot melt extrusion technology, and medicine is rapidly released in a buffer solution with the pH of 4.5 and still achieves medicine action; due to the adding of the auxiliary materials, the preparation has the advantages that disintegrating is rapid, mouthfeel is good, dissolution is rapid, swallowing is easy, irritation to the mouth mucosa is avoided, and the compliance of animal medicine taking is improved. In addition, the technology is advanced, easy to operate, safe, free of pollution and suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a taste-masking orally disintegrating preparation of flunixin meglumine and a preparation method thereof. Background technique [0002] Flunixin meglumine (Flunixin meglumine) is a new type of non-steroidal animal-specific antipyretic, analgesic and anti-inflammatory drug, which has been approved for cattle, horses, pigs, dogs, cats and other animals at home and abroad. It is mainly used to relieve visceral colic, pain caused by muscle and bone disorders and anti-inflammation in horses; to control acute inflammation caused by various diseases and infections in cattle, such as laminitis and arthritis; in addition, it can also be used in sow udders Adjuvant treatment of inflammation, metritis and agalactia; in pets, it is used for muscle pain and endotoxemia in dogs and cats. [0003] The raw material of flunixin meglumine has a strong pungent taste, which ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/44A61K47/10A61P29/00
Inventor 何家康聂海英彭健波梁正敏徐杨峰
Owner GUANGXI UNIV
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