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Traditional Chinese medicine composition for treating psoriasis

A composition and technology for psoriasis, applied in the directions of drug combinations, skin diseases, pharmaceutical formulations, etc., can solve the problems of increasing drug toxicity, increasing drug dosage, and difficulty in quality control, reducing cardiovascular events, The effect of reducing the smell of medicine and improving the quality of life

Active Publication Date: 2016-01-06
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The applicant discovered a traditional Chinese medicine compound prescription for the treatment of psoriasis clinically in the early stage, and applied for and obtained the patent authorization (patent number ZL200910091066.5). Due to its many flavors and difficult quality control, the applicant team discovered after several years of exploration The effect of treating psoriasis can also be exerted when the prescription is reduced and the dosage is increased. The second patent (201210183904.3) has been applied for. However, due to the increase of the dosage, the toxicity of the drug is also increased.

Method used

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  • Traditional Chinese medicine composition for treating psoriasis
  • Traditional Chinese medicine composition for treating psoriasis
  • Traditional Chinese medicine composition for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription 1:

[0029] Radix Paeoniae Rubra 9g, Zedoary Curcuma 6g, Zhongjiefeng (Jiujie Tea) 15g, Smilax Smilax 15g, Ume 6g.

[0030] Preparation:

[0031] The above medicinal materials are soaked in 10 times the amount of water for 0.5 hours, extracted twice, the extract is filtered, the filtrate is concentrated to a relative density of 1.07-1.09, spray-dried, the dry powder is mixed evenly with starch, magnesium stearate, etc., and compressed into tablets.

Embodiment 2

[0033] Prescription 2

[0034] Radix Paeoniae Rubra 15g, Zedoary Curcuma 3g, Zhongjiefeng (Jiujie Tea) 20g, Smilax Smilax 10g, Black Plum 15g.

[0035] The above medicinal materials are soaked in 70% ethanol for 0.5h, refluxed twice for 0.5h each time, filtered, the filtrate is concentrated to a relative density of 1.13-1.15, sucrose powder is added, granulated, dried, and granulated to make a granule.

Embodiment 3

[0036] Embodiment 3 clinical research results:

[0037] 1.1 Diagnostic criteria

[0038] Western medicine diagnostic criteria for psoriasis vulgaris: (Guidelines for the Treatment of Psoriasis 2008 Edition - Recommended by the American Academy of Dermatology; Yang Guoliang, Wang Xiasheng. Modern Dermatology. Shanghai: Shanghai Medical University Press, 2005)

[0039] The basic lesions are red papules or maculopapules at the beginning, ranging from millet to mung bean, covered with layers of silvery white scales, with less acute scales and more chronic lesions. After the scales are scraped off, there is a red shiny film underneath, which is called film phenomenon. Scattered small bleeding spots appear in the form of dewdrops (Auspitz phenomenon) when the film is lightly scraped. Occur in the scalp, elbows, knees, joint extensors and sacrum. Deck pitting and under-deck oil dripping. Mucous membranes were seen as red patches with well-defined margins, without scales. Lips ma...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating psoriasis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of radix paeoniae rubra, 3-9 parts of rhizoma curcumae, 10-20 parts of glabrous sarcandra herb, 10-20 parts of rhizoma smilacis glabrae and 5-15 parts of dark plum. The traditional Chinese medicine composition has the following benefits: the treating effect can be achieved by virtue of a relatively small dose, the toxicity is remarkably reduced, the traditional Chinese medicine composition takes effect relatively fast, and recurrence can be delayed; the traditional Chinese medicine has a more outstanding effect on common psoriasis (PASI 50 can reach 60%); especially for an early-onset psoriasis patient, such complications as cardiovascular events, psoriasis arfhropathica and diabetes can be reduced (for a patient who takes the traditional Chinese medicine composition, the complication rate can be lowered by 20%); therefore, the traditional Chinese medicine composition can remarkably improve the life quality of the psoriasis patients, and has a better effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating skin diseases. Background technique [0002] Psoriasis is a genetically predisposed, systemic, chronic, inflammatory skin disease. It is typically characterized by recurrent scaly erythema or papules with itching or pain, with filmic phenomena and spotting. Nails and joints can also be affected. Its pathogenesis is not yet fully understood, and it is mainly related to epidermal keratinocytes and immune dysfunction, involving complex immune and inflammatory responses. At present, there are 125 million patients with psoriasis in the world, and the prevalence rate accounts for 3% of the world's population, and it shows an increasing trend year by year. Worldwide, the highest prevalence of psoriasis is 8.2% in Norway. The total prevalence rate in my country is 0.72%, and there are 10 million patients at present. According to the comparative results of two large-scale psor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P17/06
CPCA61K36/9066A61P17/06A61K36/61A61K36/65A61K36/896A61K2300/00
Inventor 卢传坚赵瑞芝禤国维韩凌陈更新闫玉红刘丽娟
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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