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High-content glucosamine sulfate tablet and preparation method

A technology of glucosamine sulfate and glucosamine sulfate potassium salt, applied to medical preparations containing active ingredients, sugar-coated pills, pharmaceutical formulas, etc., which can solve the problems of low content of effective drugs, low bioavailability, and low content of glucosamine , to achieve the effect of round and smooth appearance, lower production cost and simple preparation process

Inactive Publication Date: 2015-12-30
BEIJING KANGLIJI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of glucosamine in the invention is relatively low, and patients need to take it two or more times a day
Most of the commercially available glucosamine products have less effective drug content and low bioavailability

Method used

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  • High-content glucosamine sulfate tablet and preparation method
  • High-content glucosamine sulfate tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation prescription: 87 parts of D-glucosamine sulfate potassium salt, 2.5 parts of povidone K30, 2.2 parts of microcrystalline cellulose, 1.5 parts of sodium carboxymethyl starch, 0.8 parts of magnesium stearate, 0.5 parts of silicon dioxide, film pack 1.3 parts of clothing powder, 4 parts of ultrapure water.

[0027] Preparation process: filter D-glucosamine sulfate potassium salt, microcrystalline cellulose, povidone K30 and carboxymethyl starch sodium through a 80-mesh sieve. Accurately weigh the above raw materials according to the formula, add them to the mixing granulator for crushing and stirring. Add an appropriate amount of ultrapure water, pass through a 20-mesh sieve and granulate. Put the granules into the dryer to remove moisture, set the fan frequency to 25Hz, the inlet air temperature to 65°C, and the temperature of the material to be about 45°C. After drying, the moisture content of the granules decreases. Add lubricant magnesium stearate and gl...

Embodiment 2

[0029] Preparation prescription: 91 parts of D-glucosamine sulfate potassium salt, 2.7 parts of povidone K30, 2.1 parts of microcrystalline cellulose, 2.2 parts of sodium carboxymethyl starch, 0.4 parts of magnesium stearate, 0.4 parts of silicon dioxide, film pack 0.8 parts of clothing powder, 5 parts of ultrapure water.

[0030] Preparation process: filter D-glucosamine sulfate potassium salt, microcrystalline cellulose, povidone K30 and carboxymethyl starch sodium through a 80-mesh sieve. Accurately weigh the above raw materials according to the formula, add them to the mixing granulator for crushing and stirring. Add an appropriate amount of ultrapure water, pass through a 20-mesh sieve and granulate. Put the granules into the dryer to remove moisture, set the fan frequency to 35Hz, the inlet air temperature to 75°C, and the temperature of the material to be about 50°C. After drying, the moisture content of the granules decreases. Add lubricant magnesium stearate and gl...

Embodiment 3

[0032] Preparation prescription: 90 parts of D-glucosamine sulfate potassium salt, 2.9 parts of povidone K30, 2.4 parts of microcrystalline cellulose, 1.7 parts of carboxymethyl starch sodium, 0.5 parts of magnesium stearate, 0.6 parts of silicon dioxide, film pack 1.2 parts of clothing powder, 6 parts of ultrapure water.

[0033] Preparation process: filter D-glucosamine sulfate potassium salt, microcrystalline cellulose, povidone K30 and carboxymethyl starch sodium through a 80-mesh sieve. Accurately weigh the above raw materials according to the formula, add them to the mixing granulator for crushing and stirring. Add an appropriate amount of ultrapure water, pass through a 20-mesh sieve and granulate. Put the granules into the dryer to remove moisture, set the fan frequency to 45Hz, the inlet air temperature to 85°C, and the temperature of the material to be about 55°C. After drying, the moisture content of the granules is reduced. Add lubricant magnesium stearate and g...

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Abstract

The invention discloses a high-content glucosamine sulfate tablet and a preparation method. The high-content glucosamine sulfate tablet is prepared from the following raw materials in parts by weight: 87-93 parts of a D-glucosamine potassium sulfate salt, 2.5-3.0 parts of a binder, 2-2.5 parts of a filler, 1.5-2.5 parts of a disintegrant, 0.4-0.8 part of a lubricating agent, 0.4-0.7 part of a flow aid and 0.7-1.3 parts of film coating powder. The method comprises the following steps: adding the D-glucosamine potassium sulfate salt, the binder, the filler and the disintegrant to a mixing granulator, and crushing and stirring the raw materials; adding a proper amount of wetting agent for pelletizing; drying particles to remove the wetting agent; adding the lubricating agent and the flow aid, granulating, fully mixing and tabletting to prepare a tablet core; and finally coating the tablet core with the film coating powder. The high-content glucosamine sulfate tablet disclosed by the invention is high in effective component content, good in bioavailability and convenient to take; and only one tablet needs to be taken a day.

Description

technical field [0001] The invention relates to a high-content glucosamine sulfate tablet and a preparation method thereof, belonging to the field of medicine and health care products. Background technique [0002] Glucosamine is a derivative of natural amino monosaccharide, which is an important component necessary for the synthesis of proteoglycan in cartilage matrix. Proteoglycan can reduce the impact force of articular cartilage by inhibiting the stretching force of collagen fibers. After glucosamine enters the human body, it promotes the body to produce an appropriate amount of joint synovial fluid, thereby continuously lubricating and repairing the surface of articular cartilage, reducing friction, repairing the worn or eroded articular cartilage and surrounding soft tissue, so that the articular cartilage returns to normal and joint activities are flexible and free . Glucosamine and its salts have a good curative effect on treating rheumatoid arthritis inflammation,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/7008A61P19/02A61P29/00
Inventor 佘佐彦熊佳佳
Owner BEIJING KANGLIJI BIOLOGICAL TECH CO LTD
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