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artificial blood vessel

A technology of artificial blood vessels and multifilament yarns, applied in the field of artificial blood vessels, can solve the problems of insufficient practicability of artificial blood vessels, achieve the effects of inhibiting blood leakage from artificial blood vessels, reducing strength deterioration, and improving cell settlement

Inactive Publication Date: 2017-03-08
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when used as an artificial blood vessel with a small diameter (inner diameter less than 6mm), it is difficult to maintain the non-occlusive state for a long time due to thrombus formation, and the practicability as an artificial blood vessel for transplantation is still insufficient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The warp and weft yarns (back side yarns) use polyester fibers with a single fiber fineness of 1.38dtex and a multifilament yarn A of a total fineness of 33dtex; Sea-island fiber (sea / island (mass ratio) = 20 / 80 ratio, island component fraction 70), single fiber fineness 7.3 dtex, total fineness 66dtex, multifilament yarn B' without twisting. This multifilament B' is made into a multifilament B by superfine processing. Using the above-mentioned warp yarns, for the multifilament yarn A and the multifilament B', respectively, the multifilament yarn A is used to prepare the warp beam A and the multifilament yarn B' is used to produce the warp beam B' using the beam warping machine. Using the above-mentioned weft yarns, for the multifilament yarn A and the multifilament B', respectively, the weft shuttle A is made from the multifilament yarn A and the weft shuttle B' is made from the multifilament yarn B' using the weft winder. Use the above-mentioned warp yarn weaving be...

Embodiment 2

[0071] An artificial blood vessel including a tubular fabric was fabricated by the same method as in Example 1 except that the ratio of the multifilament yarn B was 75%. When the inner wall surface of the obtained artificial blood vessel was observed with a magnification microscope of 100 times, it was confirmed that the multifilament yarn B formed rings, and these rings existed in a dispersed state. In addition, the water permeability is 310ml / cm 2 / min, kink resistance, anti-thrombosis and cell adhesion obtained excellent results.

Embodiment 3

[0073] An artificial blood vessel including a tubular fabric was produced by the method described in Example 1 except that the ratio of the number of single fibers of the multifilament yarn B was 30% and the wall thickness was 100 μm. When the inner wall surface of the obtained artificial blood vessel was observed with a magnification microscope of 100 times, it was confirmed that the multifilament yarn B formed rings, and these rings existed in a dispersed state. Water permeability is 190ml / cm 2 / min, the kink resistance has good results, the antithrombotic property is excellent, and the cell adhesion has practical results.

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Abstract

It is an object of the present invention to provide an artificial blood vessel with excellent cell colonization that is less likely to form a thrombus when transplanted into a small-diameter or medium-diameter blood vessel while maintaining the mechanical properties of the artificial blood vessel, facilitates colonization of endothelial cells, and facilitates rapid endothelial organization. Blood vessel. The present invention provides an artificial blood vessel comprising at least two of a multifilament yarn A having a single fiber fineness of 1.0 dtex or more and a total fineness of 33 dtex or less, and a multifilament yarn B having a single fiber fineness of 0.08 dtex or less and a total fineness of 66 dtex or less. A polyester fiber tubular fabric having an inner diameter of 8 mm or less and a layer thickness of 50 μm or more and 250 μm or less, and the multifilament yarn B forms loops on the inner wall surface of the composite tubular fabric.

Description

technical field [0001] The present invention relates to an artificial blood vessel that suppresses the occurrence of occlusion due to thrombus when transplanted into a small-diameter blood vessel while maintaining mechanical properties. Background technique [0002] Artificial blood vessels are mainly used to replace diseased biological blood vessels or to form bypasses. Therefore, there are requirements for artificial blood vessels: good biocompatibility with the host, no toxicity, etc., not easy to deteriorate in the living body, strong, less blood leakage, antithrombotic, and not too expensive. [0003] As artificial blood vessels, there are cloth artificial blood vessels, polytetrafluoroethylene artificial blood vessels, biomaterial-derived artificial blood vessels, synthetic polymer material artificial blood vessels, hybrid artificial blood vessels, etc., and are selected according to the application. For example, large-caliber (inner diameter above 10 mm) artificial b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06
CPCA61F2/06A61F2250/0017A61F2250/0067A61L27/18A61L33/068C08L79/02D04B21/02D10B2509/06A61F2/89A61F2210/0076
Inventor 山田谕土仓弘至田中伸明棚桥一裕阪口有佳藤田雅规门胁功治
Owner TORAY IND INC
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