Hydrophilic chlorin photo-sensitive and sono-sensitive agent with long wavelength and preparation method and application thereof
A chlorin and long-wavelength technology, applied in the field of chemical medicine, can solve the problems of slow clearance rate, low selectivity of tumor cells, and narrow therapeutic window
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[0034]
[0035] Synthesis of compound 8a-TEL
[0036](1) Dissolve 53.2 mg of commercially available compound 1 in 10 mL of methanol, add 200 μL of concentrated sulfuric acid dropwise, stir at a temperature of 0-50 ° C, protect with nitrogen balloon, monitor by TLC, stop the reaction after 4 hours, add 20 mL of deionized water to the reaction solution , and transferred to a 125mL separatory funnel, extracted with dichloromethane (30ml×3), combined the dichloromethane layers, added anhydrous sodium sulfate to dry, suction filtered, and concentrated to obtain a crude product. The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 1:4) to obtain 44.2 mg of a dark green solid, namely chlorin 15,17-dimethyl ester, with a yield of 77%. ESI-MSm / z:625.4[M+H] + . 1 HNMR (400MHz, CDCl 3 )δ9.64(1H,s),9.50(1H,s),8.72(1H,s),8.01(1H,dd,J=17.8,11.5Hz),6.32(1H,dd,J=17.8,1.2Hz ),6.12(1H,dd,J=11.5,1.2Hz),5.51(1H,d,J=18.7Hz),5.26(1H,d,J=18.7Hz)...
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