Function and application of dual-specificity phosphatase 14 (DUSP 14) in curing cardiac hypertrophy

Abstract

The invention discloses a function and application of a dual-specificity phosphatase 14 (DUSP 14) in curing cardiac hypertrophy, belonging to the field of gene function and application. The mutual relation between the expression of the DUSP 14 and cardiac hypertrophy is determined, and research results show that in a model with cardiac hypertrophy, compared with a normal group, the expression of the DUSP 14 is remarkably reduced; inhibiting the expression of the DUSP 14 remarkably promotes cardiac hypertrophy and fibrosis and deteriorates a cardiac function, and promoting the overexpression of the DUSP 14 remarkably inhibits cardiac hypertrophy and fibrosis and protects the cardiac function. Therefore, the DUSP 14 can serve as a target gene for screening drugs capable of protecting the cardiac function, resisting cardiac fibrosis and / or preventing, relieving or curing cardiac hypertrophy, and for preparing the drugs capable of protecting the cardiac function, resisting cardiac hypertrophy and / or preventing, relieving or curing cardiac hypertrophy, thus providing an effective new approach for the curing of cardiac hypertrophy.

Description

Technical field [0001] The invention belongs to the field of function and application of genes, which specializes in the function and application of a bispecidal phosphatase 14 (DUSP14) in the treatment of myocardial hypertrophy. Background technique [0002] Myocardial hypertrophy is a compensatory response to the increased stress of long -term biomechanical or increased volume load. It is common in cardiovascular diseases such as hypertension, aortic valve stenosis.Characteristics such as increasing [1-3].Hypertension and degenerative aortic valve disease have risen year by year in my country.The incidence of myocardial hypertrophy and hypertension heart disease caused by diseases such as hypertension also increased.Although myocardial hypertrophy can initially increase myocardial cells and enhance myocardial contraction, it is a compensation mechanism that maintains normal cardiac output, but long -term continuous pressure or overweight load will cause myocardial reconstructio...

AI Technical Summary

Problems solved by technology

Although myocardial hypertrophy can initially increase myocardial cells and strengthen myocardial contractility, which is a compensatory mechanism to maintain normal cardiac output, long-term continuous pressure or volume overload will cause myocardial remodeling, and at the same time due to myocardial Increased oxygen demand and relatively insufficient coronary blood supply lead to myocardial ischemia, myocardial cell apoptosis, and decompensation, leading to heart failure, malignant arrhythmia, and even sudden death[4,5]

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