Application of zinc finger protein 394 (ZNF394) in treating myocardial hypertrophy
A zinc finger protein, a technology for cardiac hypertrophy, applied in the preparation of prevention, the function and application of zinc finger protein 394 (ZNF394) in the treatment of cardiac hypertrophy, and the application field of medicines for relieving and/or treating cardiac hypertrophy, which can solve limited problems, etc. To achieve the effect of anti-cardiac fibrosis myocardial hypertrophy, inhibition of myocardial hypertrophy, and protection of cardiac function
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[0082] [Example 1] Expression of ZNF394 in the hearts of normal people and patients with cardiomyopathy
[0083]SDS-PAGE-immunoblotting test (Westernblot) was performed on proteins extracted from the hearts of normal human hearts (individuals donated by non-cardiac causes of death) and hearts of patients with dilated cardiomyopathy (recipients replaced by patients undergoing heart transplantation, DCM). , combined with antibodies that specifically recognize ZNF394 protein and cardiomyocyte hypertrophy markers ANP (Millipore, AB2232) and β-MHC (santacruz, sc53090) to detect the expression of ZNF394 (AVIVA, ARP37322_P050), GAPDH (CellSignalingTechnology, 2128) Internal reference. Test results such as figure 1 As shown, the expression of cardiomyocyte hypertrophy markers ANP and β-MHC in the hearts of patients with dilated cardiomyopathy was significantly up-regulated, and the expression of ZNF394 was significantly down-regulated ( figure 1 );
[0084] [Example 2] Expression of...
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