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A kind of antibacterial transparent dressing and its preparation method and application

A transparent, polymer technology, applied in the field of medical devices made of polymer materials, can solve problems such as bloodstream infection and bacterial residue, and achieve the effect of facilitating healing, long-term antibacterial performance, and controlled release rate

Active Publication Date: 2018-05-18
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to data, there are 7 million patients in the United States who need central venous catheterization every year, and about 60% of them will have bloodstream infection caused by their own skin, causing serious complications, although the patient's skin will be disinfected before surgery treatment, but some bacteria still remain and regrow

Method used

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  • A kind of antibacterial transparent dressing and its preparation method and application
  • A kind of antibacterial transparent dressing and its preparation method and application
  • A kind of antibacterial transparent dressing and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Step 1, take 60 parts of 2-hydroxyethyl methacrylate, 0.1 part of azobisisobutyronitrile, 0.1 part of ethylene glycol dimethacrylate, 2 parts of chlorhexidine gluconate, 1 part of ethylene glycol and water 38 parts of the mixed solution of 1 were stirred at room temperature and 4000r / min for 30min to make a mixed solution;

[0052] Step 2, sealing the above mixed solution in a container, placing it in a 70°C water bath, stirring, reacting for 8 hours, and then stopping the reaction to obtain a polymer;

[0053] Step 3: Put the polymer prepared by the above reaction in a container filled with 100 mL of water, and change the water every 3 hours until 3 days to obtain a gel pad.

[0054] In step 4, the gel liner is adhered to the surface of the polyurethane transparent film through a medical pressure-sensitive adhesive by extrusion or pasting, and fixed to obtain an antibacterial transparent dressing.

Embodiment 2

[0056] Step 1, take 40 parts of 2-hydroxyethyl methacrylate, 0.02 part of azobisisobutyronitrile, 0.1 part of ethylene glycol dimethacrylate, 0.5 part of chlorhexidine gluconate, 1 part of ethylene glycol and water 60 parts of the mixed solution of 1 were stirred at room temperature and 4000r / min for 30min to make a mixed solution;

[0057] Step 2, sealing the above mixed solution in a container, placing it in a 70°C water bath, stirring, reacting for 8 hours, and then stopping the reaction to obtain a polymer;

[0058] Step 3: Put the polymer prepared by the above reaction in a container filled with 100 mL of water, and change the water every 3 hours until 3 days to obtain a gel pad.

[0059] In step 4, the gel liner is adhered to the surface of the polyurethane transparent film through a medical pressure-sensitive adhesive by extrusion or pasting, and fixed to obtain an antibacterial transparent dressing.

Embodiment 3

[0061] Step 1, take 80 parts of 2-hydroxyethyl methacrylate, 0.5 parts of azobisisobutyronitrile, 0.5 parts of ethylene glycol dimethacrylate, 5 parts of chlorhexidine gluconate, 1 part of ethylene glycol and water 14 parts of the mixed solution of 1 were stirred at room temperature and 4000r / min for 30min to make a mixed solution;

[0062] Step 2, sealing the above mixed solution in a container, placing it in a 70°C water bath, stirring, reacting for 8 hours, and then stopping the reaction to obtain a polymer;

[0063] Step 3: Put the polymer prepared by the above reaction in a container filled with 100 mL of water, and change the water every 3 hours until 3 days to obtain a gel pad.

[0064] In step 4, the gel liner is adhered to the surface of the polyurethane transparent film through a medical pressure-sensitive adhesive, and fixed to obtain an antibacterial transparent dressing.

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Abstract

The present invention relates to a kind of antibacterial transparent dressing and its preparation method and application, and described dressing comprises the polymer gel liner with hygroscopicity and long-term bacteriostasis performance and transparent protective film, contains in the polymer gel liner Antibacterial drug, the polymer gel liner is prepared from a material selected from the following polymer monomers: hydroxyethyl methacrylate, methyl methacrylate, phenylacrylic acid, α-cyanoacrylate, α- Carboxymethacrylic acid, methyl α-chloroacrylate, 2-hydroxyethyl acrylate, the antibacterial drug is selected from chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene guanidine salt, triclosan , the transparent protective film is a polyurethane film.

Description

technical field [0001] The invention belongs to the technical field of medical devices made of polymer materials, and in particular relates to an antibacterial transparent dressing and a preparation method and application thereof. Background technique [0002] Blood collection or administration through venipuncture is a common clinical diagnosis and treatment method. However, venipuncture destroys the natural barrier of the human body, and pathogenic microorganisms can enter the circulating blood stream to form Catheter-Related Blood Stream Infection (CRBSI). There are a large number of bacterial colonization on the skin surface of normal people, which can be divided into transient bacteria and resident bacteria. Transient bacteria are planted in the epithelial layer of the skin and can be removed by ordinary cleaning; resident bacteria live under the epithelial cells of the stratum corneum of the skin and can also be found on the surface of the skin, which is not easy to r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L33/14C08L33/12C08F220/28C08F220/14C08K5/31
Inventor 徐小雨陶秀梅牟昳尚丽霞
Owner NKD PHARMA CO LTD
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