Preparation of lisinopril sustained-release tablets

Abstract

The invention belongs to the technical field of medicine preparations, and discloses preparation of lisinopril sustained-release tablets. The lisinopril sustained-release tablets comprise, by weight, 1%-4% of lisinopril, 54%-66% of matrix materials, 18%-24% of pregelatinized starch, 14.2%-17.6% of microcrystalline cellulose and 0.4%-0.8% of magnesium stearate. The matrix materials are carbomer. The preparation of the lisinopril sustained-release tablets includes smashing the lisinopril according to the weight percentage, filtering the lisinopril via a 100-mesh sieve and then adding the lisinopril into a three-dimensional movable mixer; smashing the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate, filtering the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate via an 80-mesh sieve and then adding the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate into the three-dimensional movable mixer; mixing the lisinopril, the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate with one another by the three-dimensional movable mixer for 30 minutes to obtain mixtures and then directly compressing the mixtures to obtain the lisinopril sustained-release tablets. The preparation has the advantages that the mixtures are directly compressed without coating, so that sustained-release effects can be realized; technologies are simple, and medicine is uniform in release speed.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to the preparation of lisinopril sustained-release tablets. Background technique [0002] Lisinopril is a new generation of angiotensin-converting enzyme inhibitors, which mainly lowers blood pressure by inhibiting the renin-angiotensin-aldosterone system, and is mainly suitable for the treatment of essential hypertension. [0003] However, the onset of hypertensive diseases has the characteristics of a circadian rhythm. The blood pressure of the human body presents rhythmic changes within 24 hours. One of two important characteristics. Understanding the rhythmic changes of human blood pressure has important guiding significance for the clinical treatment of hypertension. Therefore, ideal antihypertensive drugs, in addition to having good compliance, should be able to stably lower blood pressure within 24 hours, significantly reduce the morning bloo...

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above technical problems, the patent No. 201210585996.8 discloses a lisinopril delayed-release sustained-release tablet and its preparation method. The present invention utilizes the porogen in the coating layer to gradually dissolve and form a release channel, and the tablet The drug in the core passes through these channels to achieve the effect of release, so as to achieve the effect of delayed release and slow release of the drug; the release rate is determined by the characteristics of the tablet core and the characteristics of the coating layer. Due to the complex process, process conditions and technical parameters Difficult to control, poor reproducibility, resulting in unstable release rate

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