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Composition of anti-diabetic drugs

A drug-carrying and adhesive technology, which is used in drug combination, metabolic diseases, capsule delivery, etc., can solve the problem that cylindrical tablet coating is difficult to achieve, the proportion of drug-containing coating layer is large, and the coating is uneven, etc. The problem is that the preparation scheme is reliable and easy to implement, the inspection and quality control are easy, and it is beneficial to industrialized large-scale production.

Inactive Publication Date: 2015-11-11
杭州成邦医药科技有限公司
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  • Abstract
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Problems solved by technology

Analysis of its examples shows that the proportion of the drug-containing coating layer is very large, which is difficult to achieve in the production process, and the uneven coating will also cause problems such as drug flushing; Risk of impurities from active ingredient exposure
[0007] Patent CN201220120673.7 discloses the tablet capsule of the above-mentioned compound preparation, but it is difficult to realize the cylindrical tablet coating

Method used

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  • Composition of anti-diabetic drugs
  • Composition of anti-diabetic drugs
  • Composition of anti-diabetic drugs

Examples

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preparation example Construction

[0030] The preparation method of the compound capsule containing alogliptin and pioglitazone comprises the following steps:

[0031] 1) Preparation of drug-loaded pellets: sieve the prescribed amount of alogliptin or pioglitazone and the filler respectively, mix them uniformly, prepare them in a centrifugal granulator with a binder, and place the prepared pellets at 60° C. After drying for 2 hours, the drug-loaded pills were obtained. Dissolve the coating material in the prescribed amount in distilled water, mix evenly and coat in a fluidized bed to obtain coated pellets.

[0032] 2) Filling of the coated pellets: filling the above-mentioned coated pellets of alogliptin and pioglitazone into the empty capsules according to the compatible amount of the capsule drugs using a capsule filling machine to obtain compound capsules of alogliptin and pioglitazone.

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Abstract

The invention provides a composition of anti-diabetic drugs. The composition comprises alogliptin coated pellets, pioglitazone coated pellets and a gelatin capsule shell and is used for treating type II diabetes, wherein blank pellets comprise main drugs, filling agents and adhesives; in the total blank pellets, the main drugs account for 3-12wt%, the filling agents account for 20-60wt%, blank pellet cores account for 40-80wt% and the adhesives account for 1-10wt%; the weights gained by coating layers are about 2-10% of the weights of the drug-loaded blank pellets. Alogliptin and pioglitazone pellets with different coating colors are preferentially prepared. The composition has the advantages of simple and reliable production process, low loss, good product stability and few by-products, so that the composition is beneficial to large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound capsule containing alogliptin and pioglitazone. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion and / or insulin action. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. Severe cases can cause acute complications such as dehydration, electrolyte disturbance and acid-base imbalance, ketoacidosis and hyperosmolar coma. Diabetes is clinically divided into two types: insulin-dependent (IDDM, type I) and non-insulin-dependent (NIDDM, type II). Among them, type Ⅱ diabetes accounts for about 90% to 95% of the total number of diabetic patients, and its incidence is increasing year by year worldwide, especia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/513A61P3/10A61K31/4439
Inventor 戈震
Owner 杭州成邦医药科技有限公司
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