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Application of prescriptions composed of vitamin C and baicalein in cervical cancer treatment

A technology of baicalein and vitamins, applied in the field of biomedicine, can solve problems such as no relevant reports, and achieve the effects of significant inhibition, improvement of immunity, and improvement of antioxidant capacity.

Inactive Publication Date: 2015-11-04
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing literature has shown that both baicalein and high-dose vitamin C have a certain anti-tumor effect, but there is no relevant report on the anti-tumor effect of compound baicalein and vitamin C

Method used

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  • Application of prescriptions composed of vitamin C and baicalein in cervical cancer treatment
  • Application of prescriptions composed of vitamin C and baicalein in cervical cancer treatment
  • Application of prescriptions composed of vitamin C and baicalein in cervical cancer treatment

Examples

Experimental program
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Effect test

Embodiment 1

[0014] This example is the effect of a prescription composed of vitamins and baicalein on HeLa cells. Dilute baicalein and vitamin C from 1500 μg / ml to 1500 / 32 μg / ml according to the half-dilution method, form a prescription in pairs to act on HeLa cells, and set up a single-dose group of vitamin C and baicalein for comparison, MTT The effect of the drug on HeLa at 12h, 24h, 36h, 48h, and 72h was detected. The results showed that when the drug concentration of vitamin C was lower than 1500 / 2μg / ml, the growth inhibitory effect on HeLa cells was drug concentration-dependent. When vitamin C When the drug concentration is greater than 600 μg / ml, the inhibitory effect on HeLa cells does not change much with the drug concentration; the inhibitory effect of baicalein on HeLa cells is concentration-dependent in the range of 0-1500 / 8 μg / ml.

[0015] Based on the above preliminary experiments, vitamin C and baicalein were applied to HeLa cells according to 600+50, 600+100, 600+150, 600+...

Embodiment 2

[0018] This example is the effect of a prescription composed of vitamin C and baicalein on transplanted tumors, immune organ indexes and cytokines in U14 cervical cancer tumor-bearing mice.

[0019] Mice were 18-22 weeks old, female Kunming mice. The mice successfully modeled were divided into 6 groups, 10 in each group. They were blank control group, positive control group (cyclophosphamide), negative control group, vitamin C high-dose group, vitamin C low-dose group, baicalein high-dose group, baicalein low-dose group, vitamin C+baicalein high-dose group , vitamin C + baicalein low-dose group. The positive control group was intraperitoneally injected with 0.2ml, 20mg / kg cyclophosphamide, the negative control group was given 0.2ml of distilled water, and the low-dose and high-dose vitamin groups were given 0.2ml, 60mg / kg, 0.2ml, 120mg / kg vitamin C, respectively. Baicalein low and high dose groups were fed with 0.2ml, 20mg / kg, 0.2ml, 40mg / kg baicalein, vitamin C+baicalein lo...

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Abstract

The invention discloses application of prescriptions composed of vitamin C and baicalein in cervical cancer treatment. A plurality dosages of baicalein and vitamin C form different prescriptions, and the prescriptions are compared with corresponding dosage of single baicalein and single vitamin C and act on U14 cervical cancer tumor-bearing mouse models and HeLa cells. Animal experiments show that the prescriptions composed of the vitamin C and the baicalein are better in tumor inhibiting effect and smaller in toxic and side effects as compared with single vitamin C and single baicalein. Cell experiment results show that when same medicine dosage acts on cells for 12 hours, the cells in prescription groups start to atrophy and deform, and the number of cells is reduced; when the same medicine dosage acts on the cells for 36 hours, cell structures disappear, most cells die, and the inhibiting effect of the prescription groups is evidently better than that of the single vitamin C and single baicalein groups. Therefore, the prescriptions composed of the vitamin C and the baicalein is applicable to cervical cancer treatment.

Description

technical field [0001] The invention relates to a medicine for treating tumors, in particular to the application of a prescription composed of vitamin C and baicalein in treating cervical cancer, which belongs to the field of biomedicine. Background technique [0002] Cervical cancer is a common gynecological tumor that seriously threatens women's health, ranking first among gynecological malignancies in developing countries. In women worldwide, about 371,000 new cases of invasive cervical cancer occur each year, accounting for about 10% of female malignancies. There are about 135,000 new cases in my country every year, accounting for 1 / 3 of the global incidence population summary, and about 50,000 patients die of cervical cancer every year. In recent years, the incidence of cervical cancer has a tendency to become younger. Although the incidence of cervical cancer in my country has been increasing year by year, the incidence has obviously tended to be younger in the past 2...

Claims

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Application Information

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IPC IPC(8): A61K31/375A61P35/00A61P37/04A61P15/00A61K31/352
Inventor 栗坤王洁石明李建翟越
Owner YANSHAN UNIV
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