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Blood purification membrane and preparation method thereof

A technology of blood purification and sulfonated polyethersulfone, applied in the field of medical biological materials, can solve the problems of poor barrier effect and high polymer membrane price, and achieve the effects of good water permeability, good permeability and moderate mechanical strength

Inactive Publication Date: 2015-10-21
SUZHOU JONATHAN NEW MATERIALS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the price of polymer membranes for blood purification is relatively high, and membrane materials with good permeability to solutes have poor barrier effect on bacteria and viruses, so they cannot meet the urgent needs of clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A blood purification membrane, mainly made of the following raw materials according to the ratio of parts by mass: 18 parts of collagen, 16 parts of silk protein, 8 parts of silk fibroin, 6 parts of sericin, 1 part of polyethersulfone, sulfonated polyethersulfone 1 part, 5 parts of heparin, 2 parts of lysine, 2 parts of cellulose acetate, 25 parts of double distilled water.

[0027] A method for preparing a blood purification membrane, comprising the following steps:

[0028] (1) Dissolve heparin and lysine in double distilled water to make a base solution, wherein the mass ratio of heparin, lysine and double distilled water is 1:0.5:16;

[0029] (2) Dissolve collagen, silk protein, silk fibroin and sericin in the base liquid obtained in step (1), and stir until completely dissolved;

[0030] (3) Put polyethersulfone, sulfonated polyethersulfone and cellulose acetate in a reaction kettle, make a melt at a temperature of 560°C and a pressure of 1.4MPa, dry and pulverize...

Embodiment 2

[0034] A blood purification membrane, mainly made of the following raw materials according to the ratio of parts by mass: 41 parts of collagen, 32 parts of silk protein, 16 parts of silk fibroin, 13 parts of sericin, 15 parts of polyethersulfone, sulfonated polyethersulfone 4 parts, 18 parts of heparin, 11 parts of lysine, 9 parts of cellulose acetate, 49 parts of double distilled water.

[0035] A method for preparing a blood purification membrane, comprising the following steps:

[0036] (1) Dissolve heparin and lysine in double distilled water to make a base solution, in which the mass ratio of heparin, lysine and double distilled water is 3:1:32;

[0037] (2) Dissolve collagen, silk protein, silk fibroin and sericin in the base liquid obtained in step (1), and stir until completely dissolved;

[0038] (3) Put polyethersulfone, sulfonated polyethersulfone and cellulose acetate in a reaction kettle, make a melt at a temperature of 720°C and a pressure of 2.7MPa, and dry and...

Embodiment 3

[0042] A blood purification membrane, mainly made of the following raw materials according to the ratio of parts by mass: 48 parts of collagen, 37 parts of silk protein, 23 parts of silk fibroin, 19 parts of sericin, 17 parts of polyethersulfone, sulfonated polyethersulfone 7 parts, 24 parts of heparin, 14 parts of lysine, 13 parts of cellulose acetate, 58 parts of double distilled water.

[0043] A method for preparing a blood purification membrane, comprising the following steps:

[0044] (1) Dissolve heparin and lysine in double distilled water to make a base solution, wherein the mass ratio of heparin, lysine and double distilled water is 5: 2:39;

[0045] (2) Dissolve collagen, silk protein, silk fibroin and sericin in the base liquid obtained in step (1), and stir until completely dissolved;

[0046] (3) Put polyethersulfone, sulfonated polyethersulfone and cellulose acetate in a reaction kettle, make a melt at a temperature of 780°C and a pressure of 2.9MPa, dry and pu...

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Abstract

The invention discloses a blood purification membrane and a preparation method thereof. The blood purification membrane mainly comprises, by mass, 18-48 parts of collagen, 16-37 parts of silk protein, 8-23 parts of fibroin, 6-19 parts of sericin, 1-17 parts of polyether sulfone, 1-7 parts of sulfonated polyether sulfone, 5-24 parts of heparin, 2-14 parts of lysine, 2-13 parts of cellulose acetate and 25-58 parts of double distilled water. The blood purification membrane has the advantages that the prepared blood purification membrane is good in permeability for solute to be removed, and the rate of intercepting protein in blood is high; the prepared blood purification membrane has a good effect of preventing bacteria and viruses and is good in water permeability; the prepared blood purification membrane will not cause a coagulation response and pyrogen reaction; the prepared blood purification membrane has good compatibility with the blood and is appropriate in mechanical strength.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a blood purification membrane and a preparation method thereof. Background technique [0002] As we all know, due to the instinct of the organism itself to reject the invasion of foreign matter, when the artificial organ material comes into contact with the organism, a series of foreign body reactions will occur in the organism, stimulating the abnormal development of tissue cells, and even generating tumors and carcinogenesis. In order to prevent tissue cell necrosis and artificial organs from aging and decomposing and deteriorating under the action of biological body fluids and blood, the polymer materials for artificial organs must meet the following conditions: high purity, free of impurities harmful to the human body; Compatibility, that is, histocompatibility and blood compatibility, does not cause any damage to human tissue during the compatibility process, and is resis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/74B01D67/00A61M1/34
Inventor 吕少波李卓才李苏杨
Owner SUZHOU JONATHAN NEW MATERIALS TECH
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