Polyacrylic acid-calcium phosphate composite nano-drug carrier and preparing method and application thereof

A nano-drug carrier, polyacrylic acid technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of difficult pharmaceutical preparations, easy agglomeration, precipitation, etc., to avoid Toxic and side effects, environmentally friendly production process, and easy-to-obtain raw materials

Active Publication Date: 2015-10-21
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure calcium phosphate nanoparticles are easy to agglomerate and precipitate in water, and it is difficult to make intravenously injectable pharmaceutical preparations.

Method used

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  • Polyacrylic acid-calcium phosphate composite nano-drug carrier and preparing method and application thereof
  • Polyacrylic acid-calcium phosphate composite nano-drug carrier and preparing method and application thereof
  • Polyacrylic acid-calcium phosphate composite nano-drug carrier and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] First, prepare 20 mL of calcium nitrate aqueous solution, Ca 2+ The concentration is 0.0334mol / L; prepare 20mL diammonium hydrogen phosphate aqueous solution, PO 4 3- The concentration is 0.02mol / L. According to the molar ratio Ca / P=1.67, quickly pour the diammonium hydrogen phosphate solution into the calcium nitrate solution at room temperature, adjust the pH value to 10 with ammonia water, stir and mix evenly, react for 20 minutes, centrifuge to obtain the precipitate, and wash with deionized water three times After redispersing in 40mL of deionized water, polyacrylic acid was added (the concentration after adding the solution was 0.3mg / mL), and the high-energy ultrasonic probe was ultrasonically dispersed for 4 minutes to obtain a stable polyacrylic acid-calcium phosphate composite nanoparticle suspension. The average particle size (ZAve) recorded by the laser particle size analyzer is 99.2nm, and the polydispersity index (PDI) is 0.167 (such as figure 1 shown), ...

Embodiment 2

[0029] First, prepare 20 mL of calcium nitrate aqueous solution, Ca 2+ The concentration is 0.0334mol / L; prepare 20mL diammonium hydrogen phosphate aqueous solution, PO 4 3- The concentration is 0.02mol / L. According to the molar ratio Ca / P=1.67, quickly pour the diammonium hydrogen phosphate solution into the calcium nitrate solution at room temperature, adjust the pH value to 10 with ammonia water, stir and mix evenly, react for 20 minutes, centrifuge to obtain the precipitate, and wash with deionized water three times Then re-disperse in 40mL deionized water, then add polyacrylic acid (concentration after adding the solution is 0.7mg / mL), and ultrasonically disperse with a high-energy ultrasonic probe for 4 minutes to obtain a stable polyacrylic acid-calcium phosphate composite nanoparticle suspension. The average particle size (ZAve) recorded by the laser particle size analyzer is 121.9nm, and the polydispersity index (PDI) is 0.151 (such as Figure 4 shown), the scannin...

Embodiment 3

[0031] First, prepare 20 mL of calcium nitrate aqueous solution, Ca 2+ The concentration is 0.03mol / L; prepare 20mL diammonium hydrogen phosphate aqueous solution, PO 4 3- The concentration is 0.02mol / L. According to the molar ratio Ca / P=1.5, quickly pour the diammonium hydrogen phosphate solution into the calcium nitrate solution at room temperature, adjust the pH value to 9 with ammonia water, stir and mix evenly, react for 20 minutes, centrifuge to obtain the precipitate, and wash with deionized water three times Then re-disperse in 40mL deionized water, then add polyacrylic acid (the concentration after adding the solution is 0.3mg / mL), and ultrasonically disperse for 4 minutes with a high-energy ultrasonic probe to obtain a stable polyacrylic acid-calcium phosphate composite nanoparticle suspension.

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Abstract

The invention relates to a polyacrylic acid-calcium phosphate composite nano-drug carrier and a preparing method and application thereof. The preparing method includes the following steps: (1) a microcosmic salt aqueous solution is rapidly poured into a calcium source aqueous solution, ammonium hydroxide is added to adjust the pH value, even stirring is carried out, and centrifugation washing is carried out after a reaction is carried out to obtain sediment; and (2) the sediment obtained in the step (1) is dispersed into deionized water again, polyacrylic acid is added, and stable polyacrylic acid-calcium phosphate composite nanoparticle suspension liquid is obtained through ultrasonic dispersion. The polyacrylic acid-calcium phosphate composite nano-drug carrier has the beneficial effects that the process is simple, raw materials are easy to obtain, the production process is environment-friendly and safe, the preparing period is short, and the overall process can be completed within one hour. The polyacrylic acid-calcium phosphate composite nano-drug carrier is good in biocompatibility, safe and free of toxic and side effects. Loading and slow releasing of a medicine can be achieved, the toxic and side effects caused by short-time high-concentration medicines can be avoided, and the using rate of the medicines can be improved.

Description

technical field [0001] The polyacrylic acid-calcium phosphate composite nano drug carrier and its preparation method and application involved in the invention can realize the slow release of drugs and have pH value sensitivity. Background technique [0002] Due to environmental pollution, social pressure, food safety and other factors, the incidence of diseases in modern society is high, which seriously endangers human health. Clinically, wound infection and cancer require the use of a large amount of antibiotics and anticancer drugs. Simple drug therapy without drug carrier, because drug release cannot be controlled, will cause high drug concentration in a short time, produce drug side effects, low drug utilization rate, need multiple administrations, and cannot achieve long-term therapeutic effect of drugs; cancer chemotherapy drug toxicity The side effects are large, and it is difficult to achieve drug enrichment at the tumor site by itself. Nano-drug carriers can reali...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/02A61K31/65A61K31/704
Inventor 韩颖超李芳谢云飞王欣宇戴红莲李世普
Owner WUHAN UNIV OF TECH
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