Preparation method for small-diameter artificial silk fibroin blood vessel with high unblocked rate
An artificial blood vessel, small-caliber technology, applied in medical science, prosthesis, etc., can solve problems such as small-caliber blood vessel blockage, and achieve the effects of high suture force, controllable preparation process conditions, and high blasting pressure.
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Embodiment 1
[0025] Evenly coat the silk fibroin solution with a concentration of 300mg / ml on the outer wall of the metal tube, the diameter of the metal tube is 5mm, start the motor linkage device, the rotation speed is 50rpm, control the heating rod to slowly heat up to 80°C, and after the solution is dried, Terminate heating, cool to room temperature, soak in absolute ethanol or ethanol aqueous solution for 1-3 days, then remove the hollow tube from the mold surface, and dry at room temperature for 1-3 days to obtain a single layer of silk with a diameter of 5mm Su small-caliber artificial blood vessels.
Embodiment 2
[0027] The method of Example 1 was repeated, wherein the concentration of the silk fibroin solution was 500 mg / ml to obtain a silk fibroin small-diameter artificial blood vessel with a monolayer diameter of 5 mm.
Embodiment 3
[0029] The method of Example 1 was repeated, wherein the concentration of the silk fibroin solution was 500 mg / ml, and the rotation speed was 150 rpm to obtain a silk fibroin small-caliber artificial blood vessel with a monolayer diameter of 5 mm.
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