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In-situ gel spray for treating oral cavity fungal infection

A spray and gel technology, applied in the field of pharmaceutical preparations, can solve the problems of high viscosity, poor accuracy and compliance of gels, and achieve the effect of improving compliance

Inactive Publication Date: 2015-09-23
南京泽恒医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no doubt about the effect of the gel. Due to the high viscosity of the gel, the accuracy and compliance of the drug administration are poor. Usually, the assistance of other drug delivery devices is needed, and the satisfactory effect is still not achieved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 miconazole nitrate oral thermosensitive gel spray

[0031] Composition Weight percent (%)

[0032] Miconazole Nitrate 2

[0033] Poloxamer 407 20

[0034] Tween-80 1

[0035] Ethylene glycol 6

[0036] Sodium Benzoate 0.1

[0037] water 90

[0038] Add poloxamer 407 and sodium benzoate into water, fully dissolve, swell and stir evenly, then take the prescription amount of miconazole nitrate, ethylene glycol and Tween-80, add them to water while stirring, disperse evenly, and place in 10 ℃ cooling. Store statically at 10°C, vacuumize to remove air bubbles, until milky white suspension. Dispense into spray bottles and press into the spray pump head.

Embodiment 2

[0039] Example 2 Nystatin oral thermosensitive gel spray

[0040] Composition Weight percent (%)

[0041] Nystatin 5

[0042] Poloxamer 188 2

[0043] Poloxamer 407 15

[0044] Tween-60 1.5

[0045] Ethylene glycol 10

[0046] Sodium benzoate 0.2

[0047] water 65

[0048] Ethanol 20

[0049] Add poloxamer 188, poloxamer 407 and sodium benzoate to the ethanol solution (20:65), fully dissolve, swell and stir evenly, then take the prescribed amount of nystatin, ethylene glycol and Tween-60, Add to water while stirring, disperse evenly and cool at 10°C. Store statically at 10°C, vacuumize to remove air bubbles, until milky white suspension. Dispense into spray bottles and press into the spray pump head.

Embodiment 3

[0050] Example 3 Amphotericin B oral thermosensitive gel spray

[0051] Composition Weight percent (%)

[0052] Amphotericin B 2

[0053] Poloxamer 188 1

[0054] Poloxamer 470 30

[0055] Tween-80 1

[0056] Propylene Glycol 10

[0057] Propylparaben 0.1

[0058] Methylparaben 0.1

[0059] Ethanol 20

[0060] water 80

[0061] Add poloxamer 188, poloxamer 407, propylparaben and methylparaben to water, fully dissolve, swell and stir evenly, then take the prescribed amount of amphotericin B, propylene glycol and Tween-80, Add to water while stirring, disperse evenly and cool at 10°C. Store statically at 10°C, vacuumize to remove air bubbles, until milky white suspension. Dispense into spray bottles and press into the spray pump head.

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PUM

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Abstract

The invention belongs to the field of medicine preparation and relates to a new preparation for treating oral cavity fungal infection. The preparation is realized in the form of a spray preparation of oral gel and specifically contains effective dose of medicines with certain grain size, including miconazole, nystatin, amphotericin and mixture thereof; temperature-sensitive materials, including poloxamer 407, poloxamer 188 and mixture thereof; temperature-sensitive adjuvant polyols, including propylene glycol and glycerol; solvent, including water, ethanol or mixture thereof. The combination can greatly reduce the viscosity of oral-sensitive gel, so that the gel can be quantitatively and smoothly sprayed to oral affected parts to achieve a very good curative effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a new preparation for treating oral fungal infection. The preparation is realized by spraying oral gel, and has the advantages of accurate dosage, convenient use and sanitation. Background technique [0002] Candida is a common parasitic bacterium in the human body, its pathogenicity is weak, and it can only cause disease under certain conditions, so it is an opportunistic pathogen. In recent years, with the wide application of antibiotics and adrenal cortex hormones, Candida infections are increasing . Patients with malignant tumors have disordered physiological functions, poor body resistance, poor oral hygiene, and bacteria in the oral cavity are easy to multiply. Bacteria decomposes sugars to enhance fermentation and acid production, leading to local inflammation and ulcer formation. It is now believed that its basic pathology includes direct damage and indirect dam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/12A61K47/34A61P31/10A61P1/02A61K31/4174
Inventor 张自强刘宇婧
Owner 南京泽恒医药技术开发有限公司
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