Injectable bone repair material and preparation method therefor

Abstract

The invention discloses an injectable bone repair material and a preparation method therefor, and belongs to the technical field of constructing artificial internal organs through a tissue engineering method in biomedical engineering. The injectable bone repair material is a composite body composed of a support material and seed cells, with a stereo structure and physiological activity. Injectable fibrin glue is employed as the support materials, and human autologous marrow matrix stem cells are cultured to obtain seed cells. The seed cells are human marrow matrix stem cells. The histocompatibility of the human marrow matrix stem cells and fibrin glue is good, and the composite constructed bone repair material can cure clinic bone ununion successfully. The repair material integrates advantages of a cell therapy and the support material, a new means is employed, a bone ununion therapeutic method with minimal injury and complications is provided, and the repair material has wide clinic application prospects.

Description

technical field [0001] The invention belongs to the technical field of constructing artificial organs with tissue engineering methods in biomedical engineering, and in particular relates to an injectable bone repair material and a preparation method thereof. Background technique [0002] Post-traumatic nonunion is common in clinical practice, and its treatment is still difficult. Usually, measures such as replacement of internal fixators and bone grafting are taken according to the possible cause of nonunion. There are many deficiencies such as secondary damage in these methods. Autologous bone marrow injection is used to treat bone nonunion. In some patients and parts, it is difficult to inject a sufficient amount of bone marrow to affect the therapeutic effect. Concentrating bone marrow requires expensive special equipment, and collecting hundreds of milliliters of bone marrow at multiple points is difficult for patients to accept. As a major frontier topic in the field ...

AI Technical Summary

Problems solved by technology

Autologous cancellous bone grafting, as the gold standard for the treatment of delayed union or nonunion of bone, can provide the basic elements required for bone repair, including supplementing seed cells with osteogenic ability, but its disadvantages are also obvious, such as limited materials, supply Regional complications, need for open implantation and increased trauma, etc.

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