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Application of traditional Chinese medicine composition on preparation of medicines or health care products for treating oligoasthenotspermia and infertility of men

A technology of male infertility and composition, which is applied in the application field of medicine or health products, can solve the problems of limited effect, not recommending routine treatment of male infertility, high cost of gonadotropin-releasing hormone, etc., to achieve small side effects, Good clinical application prospect and good curative effect

Inactive Publication Date: 2015-09-09
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high cost and limited effect of gonadotropin-releasing hormone, it is not recommended as a routine treatment for male infertility.

Method used

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  • Application of traditional Chinese medicine composition on preparation of medicines or health care products for treating oligoasthenotspermia and infertility of men
  • Application of traditional Chinese medicine composition on preparation of medicines or health care products for treating oligoasthenotspermia and infertility of men
  • Application of traditional Chinese medicine composition on preparation of medicines or health care products for treating oligoasthenotspermia and infertility of men

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Pharmacodynamic study of traditional Chinese medicine composition on sperm motility and quality in normal male rats

[0025] 1. Materials

[0026] 1.1 Experimental animals

[0027] 40 SD rats, male, weighing 180-220 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001.

[0028] 1.2 Experimental reagents

[0029] M199 medium: Shanghai Yuanpei Biotechnology Co., Ltd. Batch number: J20216

[0030] 1.3 Experimental drugs

[0031] The traditional Chinese medicine composition capsule: Prescription: 90 parts of Radix Polygoni Multiflori, 90 parts of Polygonatum, 90 parts of Rehmannia glutinosa, 90 parts of Gorgon, 10 parts of Ziheche, 40 parts of black sesame, 90 parts of Astragalus, 90 parts of Poria cocos, 40 parts of Chinese yam, 14 parts of American ginseng, 40 parts of asparagus, 40 parts of Radix Ophiopogon, 3 parts of pearl, 7 parts of amber, 26 parts of keel, 40 parts of arborvita...

Embodiment 2

[0066] Example 2 Pharmacodynamic study of traditional Chinese medicine composition on sperm motility and quality in oligoasthenospermia model rats

[0067] 1. Materials

[0068] 1.1 Experimental animals

[0069] 50 SD rats, male, 180-220g, were purchased from Zhejiang Experimental Animal Center, license number: SCXK (Zhejiang) 2014-0001.

[0070] 1.2 Experimental reagents

[0071] Cyclophosphamide, Tonghua Maoxiang Pharmaceutical Co., Ltd., batch number: 131007. M199 medium: Shanghai Yuanpei Biotechnology Co., Ltd. Batch number: J20216.

[0072] 1.3 Experimental drugs

[0073] Traditional Chinese Medicine Composition Capsules (90 parts of Radix Polygoni Multiflori, 90 parts of Polygonatum, 90 parts of Rehmannia glutinosa, 90 parts of Gorgon, 10 parts of Ziheche, 40 parts of black sesame, 90 parts of Astragalus, 90 parts of Poria cocos, 40 parts of Chinese yam, 14 parts of American ginseng , 40 parts of Asparagus, 40 parts of Ophiopogon japonicus, 3 parts of pearl, 7 part...

Embodiment 3

[0106] Example 3 Clinical Observation on the Treatment of Male Oligospermia, Asthenospermia and Infertility by the Chinese Medicinal Composition

[0107] 1 Materials and methods

[0108] 1.1 General information: Random sampling method was used to select 120 cases of clinically diagnosed patients with male oligospermia and asthenospermia caused by kidney deficiency and essence deficiency, and then they were randomly divided into two groups, the treatment group and the control group. 60 cases in each group. The treatment group was 24 to 37 years old, with an average of 27.28±3.78 years; the course of disease was 1 to 8 years, with an average of 2.12±1.53 years. The age of the control group was 25-38 years old, with an average of 26.83±3.29 years; the course of disease was 1-8 years, with an average of 3.14±1.15 years. There was no significant difference in age distribution, course of disease and semen examination results between the two groups (P>0.05).

[0109] 1.2 Inclusion...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition on preparation of medicines or health care products for treating oligoasthenotspermia and infertility of men. The traditional Chinese medicine composition is prepared by prepared tuber of multiflower knotweed, sealwort, prepared rehmannia roots, gordon euryale seeds, placenta hominis, semen sesami nigrum, astragalus membranaceus, tuckahoe, Chinese yams, American ginseng, cochinchinese asparagus roots, radix ophiopogonis, pearls, lamber, fossil fragments, cacumen biotae and black soybeans. Results of screening researches of a large number of pharmacodynamic experiments show that by the traditional Chinese medicine composition, the sperm movement speed can be increased obviously, the number of sperms is increased, and a clinical research result also shows that the traditional Chinese medicine composition has a high treatment effect on oligoasthenotspermia and infertility of men. A test shows that the traditional Chinese medicine composition is reliable in curative effect, small in side effect and high in safety, and has a good clinic application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines or health care products for treating male oligozoospermia and asthenospermia and male infertility. Background technique [0002] In recent years, due to various factors, about 16% of couples of childbearing age suffer from infertility, and male infertility accounts for about half, and the incidence rate is on the rise every year. According to clinical research data, oligospermia and weak sperm are one of the important causes of male infertility. According to the World Health Organization standard, sperm count <20×10 6 ·mL -1 , for oligospermia; Forward motility of sperm (a grade and b grade) <50% or a grade of sperm movement <25%, for asthenozoospermia. [0003] The etiology of oligospermia and asthenospermia is complex. Western medicine beli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P15/08A23L1/29A61K35/50A61K35/10A61K35/02A61K35/618
Inventor 罗年翠王恒斌李全叶华王亦周黄韬马鸣花
Owner 雷允上药业集团有限公司
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