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Preparation process of benazepril hydrochloride tablets

A benazepril hydrochloride tablet and technology of benazepril hydrochloride, applied in the field of medicine, can solve problems such as unbearable for patients, high treatment cost, and low toxicity and side effects, and achieve the effect of not easy to relapse, reduce economic burden, and shorten the course of treatment

Inactive Publication Date: 2015-09-02
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since hypertension is a chronic disease that requires long-term medication, the treatment costs are too high, and the side effects are often unbearable for patients.
However, Chinese traditional Chinese herbal medicines take into account both specimens, small toxic and side effects, and low cost. Therefore, it is still an urgent clinical need to develop a new compound drug of Chinese and Western medicine with high efficiency, low toxicity, and treatment of both symptoms and root causes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A compound benazepril hydrochloride tablet is characterized in that it is prepared from the following raw materials,

[0021] 1 part of benazepril hydrochloride, 35 parts of turmeric, 35 parts of salvia, 35 parts of corydalis, 30 parts of cassia, 30 parts of kudzu root, 30 parts of burdock root, 25 parts of rhodiola, 25 parts of honeysuckle, 25 parts of dandelion, uncaria 25 parts, Chuanxiong 20 parts, Polygala 20 parts, Eucommia 20 parts, Gui Zhi 20 parts, Hawthorn 15 parts, Licorice 15 parts, Plantago 15 parts, Mulberry leaves 10 parts, Lycium barbarum 10 parts, Eupatorium 8 parts, red 8 parts of peony, 5 parts of Achyranthes bidentata, and 5 parts of peach kernel.

[0022] The preparation method of the compound benazepril hydrochloride tablet pharmaceutical composition is as follows:

[0023] (1) Accurately weigh the raw materials, take salvia, kudzu root, rhodiola rosea, uncaria, chuanxiong, eucommia, plantain seed, mulberry leaf, eupatorium and mix according to t...

Embodiment 2

[0029] Clinical application:

[0030] Case selection: select 90 cases of clinical hypertensive patients to conduct clinical observation on the curative effect of the compound pharmaceutical composition of the embodiment 1 of the present invention.

[0031] Case grouping: 90 cases were randomly divided into two groups, 45 cases in the treatment group and 45 cases in the control group. Patients with severe myocardial infarction, arrhythmia, congestive heart failure, secondary hypertension, and severe liver and kidney damage were excluded, and there was no history of drug allergy to calcium antagonists or angiotensin-converting enzyme inhibitors. According to the diagnostic criteria of "Clinical Guidelines for New Drugs", it was diagnosed as hypertensive disease.

[0032] Diagnostic criteria: systolic blood pressure equal to or higher than 160mmHg, diastolic blood pressure equal to or higher than 95mmHg, if one of the two is verified, it can be diagnosed as hypertension.

[003...

Embodiment 3

[0038] Example 3 typical case

[0039]Liang, 60 years old, male. Suffering from hypertension for seven or eight years, I often feel dizzy and headache. Blood pressure fluctuates between 195 / 95-210 / 100mmHg, which is diagnosed as hypertension. After taking medicine of the present invention for a course of treatment, blood pressure is 140 / 90mmHg, continues to take a course for the treatment of, blood pressure recovers normal level, does not see rebound half a year after drug withdrawal.

[0040] The above-mentioned Chinese and Western medicines used in the present invention are compatible with each other and can exert their synergistic effect on curing diseases. The ingredients of the used Chinese medicine raw materials have the effects of mutual interweaving, mutual promotion and coordination, which not only greatly reduces the side effects caused by antibiotics, but also reduces the side effects of antibiotics. The effect is long-lasting, and through clinical verification, th...

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PUM

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Abstract

The invention relates to a preparation process of benazepril hydrochloride tablets which are traditional Chinese and western medicine composited preparations. The benazepril hydrochloride tablets are prepared from the following raw materials: 1 part of benazepril hydrochloride, 35 parts of curcuma aromatic, 35 parts of the root of red-rooted salvia, 35 parts of rhizoma corydalis, 30 parts of semen cassiae, 30 parts of the root of kudzu vine, 30 parts of burdock root, 25 parts of rhodiola rosea, 25 parts of honeysuckle, 25 parts of dandelion, 25 parts of uncaria rhynchophylla, 20 parts of ligusticum wallichii, 20 parts of polygala tenuifolia, 20 parts of eucommia ulmoides, 20 parts of cassia twig, 15 parts of hawthorn, 15 parts of liquorice, 15 parts of semen plantaginis, 10 parts of folium mori, 10 parts of the fruit of Chinese wolfberry, 8 parts of herba lycopi, 8 parts of root of common peony, 5 parts of the root of bidentate achyranthes, and 5 parts of peach kernel. The composition medicine can treat both symptoms and root causes of hypertension, is small in side effect, small in price, and simple and convenient to prepare, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation process of benazepril hydrochloride tablets. Background technique [0002] Hypertension (hypertensive disease) is a chronic disease characterized by continuous increase in arterial blood pressure, which often causes lesions in the heart, brain, kidney and other important organs with corresponding consequences. The blood pressure standard recommended by the World Health Organization is: the systolic blood pressure of normal adults should be less than or equal to 140mmHg, and the diastolic blood pressure should be less than or equal to 90mmHg. That is, the systolic blood pressure is between 141-159mmHg and the diastolic blood pressure is between 91-94mmHg, which is borderline hypertension and generally requires clinical observation. When diagnosing hypertension, blood pressure must be measured multiple times, and the average diastolic blood pressure of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K36/9066A61P9/12A61K31/55
Inventor 林凡儒徐步玺胡百忠王德栋吴士平孙永喜刘倩
Owner XIANGYU PHARMA
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