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Medical application of Marasmius androsaceus sp. T08 to the preparation of analgesic drug

A technology of Anluo Xiaopi umbrella and medicine, which is applied in the field of medicine, can solve the problems such as unmet needs of pain control, and achieve good clinical curative effect

Active Publication Date: 2015-08-26
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether Acute Pain or Chronic Pain, there is a clinically unmet need for pain control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Put Anluo Xiaopi T08 through a fermenter to obtain the fermentation liquid, centrifuge it at 5000 rpm for 10 minutes, discard the supernatant, precipitate and freeze-dry to obtain Anluo Xiaopi mushroom powder, which is 4 times the amount of 90% ethanol Reflux extraction twice, 2 hours each time, filter and recover the ethanol extract, concentrate to a relative density of 1.20 at room temperature, and vacuum dry to obtain the ethanol extract.

Embodiment 2

[0015] Put Anluo Xiaopi T08 through a fermenter to obtain the fermentation liquid, centrifuge it at 4000 rpm for 10 minutes, discard the supernatant, and freeze-dry the precipitate to obtain Anluo Xiaopi mushroom powder, which is 6 times the amount of 85% ethanol Reflux extraction twice, 2 hours each time, filter and recover the ethanol extract, concentrate to a relative density of 1.20 at room temperature, and vacuum dry to obtain the ethanol extract.

Embodiment 3

[0018] In order to prove its analgesic effect, the inventor prepared according to the method provided in Examples 1-3 Anluo Small Leather Umbrella T08 Extract, carried out pharmacodynamic experiment, research result is as follows:

[0019] 1. mouse writhing test

[0020] Get 40 healthy Kunming mice, half male and half male, with an average body weight of 18-20 g, randomly divided into blank group (normal saline, 0.2 ml), embodiment group (1.0 g / kg, 0.2 g / kg and 0.05 g / kg) , 10 in each group. Each group was intraperitoneally injected with 0.2 mL of 1.0% acetic acid 30 minutes after intragastric administration, and the writhing reaction of the mice was observed within 5-25 minutes after the injection of acetic acid (writhing reaction: mouse abdomen concave, hind limbs stretched, buttocks lifted) times. The reaction occurred most frequently within 15-20 min after the injection of acetic acid, so the total number of writhing within 20 min after the injection of acetic aci...

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PUM

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Abstract

The present invention provides medical application of Marasmius androsaceus sp. T08 to the preparation of analgesic drugs. The Marasmius androsaceus sp. is subjected to fermentation, ethanol extraction and vacuum drying to prepared a Marasmius androsaceus sp. T08 extractive. Animal experiments prove that the Marasmius androsaceus sp. T08 extractive has significant analgesic activity. The preparation method in the invention is simple and low cost, and can be applied to preparation of analgesic drugs.

Description

technical field [0001] The invention provides a medical application of Anluo Xiaopisan T08 in preparing analgesics, and relates to the technical field of medicine. Background technique [0002] Pain is a complex physiological and psychological activity, including the pain sensation caused by noxious stimuli acting on the body, and the body's pain response to noxious stimuli. Pain can be used as a warning that the body is injured, causing a series of defensive protective reactions of the body, but some acute or long-term severe pain is an unbearable torture to the body. Pain is one of the most common clinical symptoms, and it is also an important problem that medical workers need to solve urgently. [0003] In terms of the course of the disease, pain can be divided into acute pain and chronic pain. Acute pain is pain that is new and of short duration, usually associated with injury or disease. Chronic pain refers to pain that lasts for a long time. It may be that the acute...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P29/00
Inventor 滕利荣曹家铭逯家辉宋佳孟庆繁孟令军蔡广胜权宇彤姜丹
Owner JILIN UNIV
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