Pharmaceutical compositions of lysine vitamins comprising chiral isomeric compounds and uses thereof

A vitamin and lysine technology, applied in the field of medicine, can solve the problems of increased pressure from environmental protection, inability to optimize, waste, etc., achieve the effects of reducing production costs and transportation costs, increasing D-calcium pantothenate, and good calcium supplementation effect

Active Publication Date: 2019-07-12
江西兼济堂农业开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many deficiencies in the preparations of the prior art. Its lysine hydrochloride contains half of D-lysine and L-lysine, and only L-lysine is easily absorbed and utilized by the body, which has great utilization for the human body. value, and D-lysine is not easy to be absorbed and utilized by the human body; although L-lysine hydrochloride granules whose name is limited to a single optical isomer are also publicly reported, they are limited to single-component administration
In addition, vitamin lysine granules in the prior art also exist in some cases and are not suitable for patients with hyperchloremia, acidosis and renal insufficiency, etc., especially taking them when they are unknown or difficult to know may cause Adverse consequences; and the current formulation does not limit the use of L-lysine, which makes the quality or nutritional or therapeutic value of the formulation or limited or can not be optimized; moreover, the current composition is doubled dose Add half of the D-lysine that is not easy to be absorbed and utilized in the preparation of the unit hour. The larger the dosage of a unit, the longer the taking time and the greater the waste
This causes problems in manufacturing, taking convenience, transportation and packaging, or it is not suitable for clinical application, and it is not conducive to saving human resources and building a resource-saving society. This unfavorable situation has been ignored and improved for many years. , redundant packaging and increased pressure on environmental protection, but has not yet broken through the old framework

Method used

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  • Pharmaceutical compositions of lysine vitamins comprising chiral isomeric compounds and uses thereof
  • Pharmaceutical compositions of lysine vitamins comprising chiral isomeric compounds and uses thereof
  • Pharmaceutical compositions of lysine vitamins comprising chiral isomeric compounds and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of embodiment 1 vitamin lysine capsules, prescription (1000): L-lysine hydrochloride 200g, vitamin B 1 3g, vitamin B 2 1.5g, vitamin B 6 0.2g, D-calcium pantothenate 1g, zinc gluconate 6.3g; preparation process: take the prescription amount, each component passed through a 100 mesh sieve is mixed uniformly according to the equal incremental dilution method, and mixed according to the equal incremental dilution method Uniformity, measure the content of the main drug L-lysine hydrochloride in the granules, fill capsules according to the dose, pack, test, and obtain the finished product.

Embodiment 2

[0041] The preparation of embodiment 2 vitamin lysine capsules, prescription (1000): L-lysine 200g, vitamin B 1 3g, vitamin B 2 1.5g, vitamin B 6 0.2g, D-calcium pantothenate or D-calcium pantothenate 2 hydrate 1g, zinc gluconate 3 hydrate 6.3g; preparation process: take the prescription amount, each component passed through a 100-mesh sieve is diluted by the method of equal increments Mix evenly by method, measure the content of the main drug L-lysine in the granules, fill capsules according to the dose, pack, test, and obtain the finished product.

Embodiment 3

[0042] The preparation of embodiment 3 vitamin lysine capsules, prescription (1000): L-lysine acetate 200g, vitamin B 1 3g, vitamin B 2 1.5g, vitamin B 6 0.2g, D-calcium pantothenate 1g, zinc gluconate 6.3g; preparation process: take the prescription amount, each component passed through a 100-mesh sieve, mix evenly according to the method of equal incremental dilution, and measure the L-lysine acetate in the granules After the content of the acid is qualified, the capsules are filled according to the dose, packaged, inspected, and the finished product is obtained.

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PUM

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Abstract

The invention provides a chiral isomeric compound included lysine vitamin drug composition and an application of the composition in health-care food or drugs. The composition is capable of preventing or treating human and mammal L-lysine and vitamin deficiency, retained growth, the loss of appetite, malnutrition, rickets, osteoporosis, craniocerebral trauma, immunity enhancement and the like. Clinically, new intended populations are provided, or good pertinence and clinical safety and the like are provided.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to provide prevention or treatment to promote normal growth and development or supplement L-lysine for patients with L-lysine deficiency, or metabolic acidosis, hyperchloremia but need to supplement lysine Lysine vitamin pharmaceutical composition or compound lysine pharmaceutical composition containing chiral isomeric compound and its preparation and application. Background technique [0002] Lysine is a basic amino acid and has three basic forms: DL-lysine, D-lysine and L-lysine. L-lysine is one of the eight essential amino acids for the human body. L-lysine Provides structural components for the synthesis of carnitine, which drives the synthesis of fatty acids in cells. Especially in the period of child development, recovery after illness, pregnancy and lactation, the demand for L-lysine is higher. Due to its low content in foods such as rice and corn, it is easy to cause defi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/525A61P3/02A61P1/14A61P19/08A61P19/10A61P25/00A61P37/04A23L33/10A61K31/51A61K31/4415A61K31/197A61K31/191A61K31/198A23L33/00
Inventor 刘力
Owner 江西兼济堂农业开发有限公司
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