Anti-deposition nanometer silver particle coating biliary stent and preparation method thereof

A technology of nano-silver particles and bile duct stents, which is applied in coating, nano-technology, metal material coating process and other directions, can solve the problems of easy occurrence of danger and violent reaction, and achieves a stable and difficult to agglomerate, avoids violent reaction, and has good stability. Effect

Inactive Publication Date: 2015-08-19
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, active metal sodium is used in the preparation method of this patent, and the reaction is relatively violent, which is prone to danger.

Method used

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  • Anti-deposition nanometer silver particle coating biliary stent and preparation method thereof
  • Anti-deposition nanometer silver particle coating biliary stent and preparation method thereof
  • Anti-deposition nanometer silver particle coating biliary stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: Preparation of nano-silver particle-coated bile duct stent

[0051] (1) Soak the bile duct stent to be treated in absolute ethanol, ultrasonically oscillate for 1 hour, and inject absolute ethanol into the interior of the bile duct stent with a syringe to control the generation of no bubbles inside the bile duct stent;

[0052](2) Take out the bile duct stent treated in step (1), dry it, place it in the sodium naphthalene treatment solution, and corrode it for 4 hours;

[0053] (3) ultrasonically cleaning the bile duct stent treated in step (2) with water for 5 minutes, continuously flushing the inner wall of the bile duct stent with a flushing ball, and removing the naphthalene sodium treatment solution remaining on the surface of the bile duct stent and in the lumen;

[0054] (4) Put the bile duct stent cleaned in step (3) into the roughening solution for roughening treatment, the treatment temperature is 35°C, and the treatment time is 40 minutes; the roug...

Embodiment 2

[0061] Example 2: Preparation of nano-silver particle-coated bile duct stent

[0062] (1) Soak the bile duct stent to be treated in absolute ethanol, ultrasonically oscillate for 1.5 hours, and inject absolute ethanol into the interior of the bile duct stent with a syringe to control the generation of no bubbles inside the bile duct stent;

[0063] (2) Take out the bile duct stent treated in step (1), dry it, place it in the sodium naphthalene treatment solution, and corrode it for 3 hours;

[0064] (3) ultrasonically cleaning the bile duct stent treated in step (2) with water for 5 minutes, continuously flushing the inner wall of the bile duct stent with a flushing ball, and removing the naphthalene sodium treatment solution remaining on the surface of the bile duct stent and in the lumen;

[0065] (4) Put the bile duct stent cleaned in step (3) into the roughening solution for roughening treatment, the treatment temperature is 40°C, and the treatment time is 30 minutes; the ...

Embodiment 3

[0071] Example 3: Preparation of nano-silver particle-coated bile duct stent

[0072] (1) Soak the bile duct stent to be treated in absolute ethanol, ultrasonically oscillate for 1 hour, and inject absolute ethanol into the interior of the bile duct stent with a syringe to control the generation of no bubbles inside the bile duct stent;

[0073] (2) Take out the bile duct stent treated in step (1), dry it, place it in the sodium naphthalene treatment solution, and corrode it for 5 hours;

[0074] (3) ultrasonically cleaning the bile duct stent treated in step (2) with water for 5 minutes, continuously flushing the inner wall of the bile duct stent with a flushing ball, and removing the naphthalene sodium treatment solution remaining on the surface of the bile duct stent and in the lumen;

[0075] (4) Put the bile duct stent cleaned in step (3) into the roughening solution for roughening treatment, the treatment temperature is 38°C, and the treatment time is 40 minutes; the rou...

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Abstract

The present invention discloses an anti-deposition nanometer silver particle coating biliary stent and a preparation method thereof, wherein a biliary stent is soaked with dehydrated alcohol and then washed, the biliary stent is etched by using a sodium naphthalene treatment liquid, then a roughening solution, a sensitization solution and an activation solution are sequentially used to treat, and hydrogen peroxide low temperature plasma sterilization is performed to obtain the nanometer silver particle coating biliary stent. According to the present invention, the costing thickness of the prepared nanometer silver particle coating biliary stent is 1.5-6 [mu]m, the particle size distribution of the nanometer silver particles is 60-80 nm, agglomeration is not easily generated, the particle dispersion is good, and the good anti-biliary deposition effect is provided.

Description

technical field [0001] The invention relates to a nano-silver particle-coated bile duct stent with anti-deposition effect and a preparation method thereof. Background technique [0002] Endoscopic ERCP approach to place bile duct stents is one of the most commonly used clinical treatment methods. It is widely used in hepatobiliary and pancreatic diseases. It can effectively relieve obstructive jaundice, severe acute pancreatitis and other common diseases. Restoring enterohepatic circulation, blocking inflammatory response pathways, and improving prognosis. [0003] After the ordinary plastic bile duct stent is inserted into the common bile duct, the common bile duct is stimulated, showing an inflammatory reaction, and the bile duct wall is thickened and edematous. Reducing the reflux of duodenal contents, the bacteria in the duodenal lumen can reflux into the bile duct, potentially increasing biliary system infection and causing stent obstruction. Studies have shown that t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C18/44C23C18/28C23C18/30B82Y40/00
Inventor 田虎付真张帅夏明峰
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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