Compound levofloxacin hydrochloride injection and preparation method thereof

Abstract

The invention discloses a compound levofloxacin hydrochloride injection and a preparation method thereof, relates to an injection and a preparation method thereof and particularly provides a drug for treating piglet diarrhea. Bacteria have no resistance to the drug, and the drug has the advantages of wide antibacterial range, long half-life period, low drug residue and the like. The compound levofloxacin hydrochloride injection is prepared from palmatine, levofloxacin hydrochloride, a compound organic solvent, a surfactant, an antioxidant and injection water. The preparation method comprises the steps of 1, weighing raw materials; 2, dissolving palmatine; 3, dissolving levofloxacin hydrochloride; 4, adding the antioxidant; 5, mixing; and 6, adding the residual injection water, encapsulating and sterilizing. Through the mutual matching of traditional Chinese medicines and western medicines, the compound levofloxacin hydrochloride injection disclosed by the invention takes an effect of treating both symptoms and root causes; and the antibacterial range of the drug is widened, the piglet diarrhea can be prevented and controlled, the survival rate of a pig group can be increased, and the breeding efficiency can be increased.

Description

technical field [0001] The invention relates to an injection and a preparation method thereof. Background technique [0002] coli, Salmonella, Pasteurella multocida, enterotoxigenic Escherichia coli (ETEC), small rotavirus, enterotype adenovirus, Borrelia hyodysenteriae, porcine epidemic diarrhea virus (PEDV) and porcine infectious gastrointestinal Piglet diarrhea caused by TGEV and other causes is a typical multi-pathogenic disease under the conditions of intensive pig production. It occurs repeatedly from the beginning of winter to the beginning of spring, the incidence rate is high, and the course of disease is 5 to 10 days. Sick pigs have uneven skin temperature, cold ears and nose, runny nose, abdominal distension and borborygmus, aversion to cold and cold lying down, decreased or no appetite, no fever or mild fever, more than ten times of daily diarrhea, clear and thin stool , showing progressive weight loss, rapid dehydration and fat loss after one day of diarrhea. ...

AI Technical Summary

Problems solved by technology

If it is not treated in time, it will easily lead to the death of piglets and bring huge economic losses to pig farms and farmers

[0003] Bacteria have a certain tolerance to antibacterial drugs. Once drug resistance occurs, the chemotherapeutic effect of the drug will be significantly reduced; therefore, the therapeutic effect of monomeric antibacterial drugs is getting worse and worse, and even lead to secondary infections and other diseases.

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