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Application of Periplaneta americana in preparation of medicine for treating bronchopneumonia

A technology of bronchopneumonia and Periplaneta americana, applied in the application field of Periplaneta americana in the preparation of medicines for treating bronchopneumonia, can solve the problems of no bronchopneumonia and bronchitis, etc., and achieve the enhancement of body immunity, good application prospects, The effect of eliminating inflammation and edema

Active Publication Date: 2019-06-04
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no related reports on the treatment of bronchopneumonia and bronchitis with the extract of Periplaneta americana

Method used

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  • Application of Periplaneta americana in preparation of medicine for treating bronchopneumonia
  • Application of Periplaneta americana in preparation of medicine for treating bronchopneumonia
  • Application of Periplaneta americana in preparation of medicine for treating bronchopneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The ultra-high pressure extraction method of embodiment 1 Periplaneta americana

[0031] Weigh 1000g of Periplaneta americana, crush it into powder, add 6 times the amount (v / w) of 60% ethanol, and pack it into a flexible container to seal it. Put it in an ultra-high pressure extractor, increase the pressure to 300MPa, pressurize 5 times, each time for 5min, the temperature is 40°C, release the pressure, open the cover to take a sample, and filter. The filtrate was concentrated under reduced pressure at 60°C until there was no ethanol smell, and the relative density was 1.05 (measured at 50°C). The concentrated solution was refrigerated at 0°C for 24 hours, and the upper layer of oil was absorbed with filter paper, and the lower layer was centrifuged in a high-speed refrigerated centrifuge. The temperature is 5°C, and the rotation speed is 10000r / min. The centrifuged supernatant was concentrated under reduced pressure at 60°C, dried and pulverized to obtain 450 g of th...

Embodiment 2

[0032] The ultra-high pressure extraction method of embodiment 2 Periplaneta americana

[0033] Weigh 1000g of Periplaneta americana, crush it into powder, add 7 times the amount (v / w) of 75% ethanol, and pack it into a flexible container to seal it. Put it in an ultra-high pressure extractor, increase the pressure to 400MPa, pressurize 3 times, each time for 10min, the temperature is 50°C, release the pressure, open the cover to take a sample, and filter. The filtrate was concentrated under reduced pressure at 70°C until there was no ethanol smell, and the relative density was 1.08 (measured at 50°C). The concentrated solution was refrigerated at 5°C for 36 hours, and the upper layer of oil was absorbed with filter paper, and the lower layer was centrifuged in a high-speed refrigerated centrifuge. The temperature is 10°C, and the rotation speed is 10000r / min. The centrifuged supernatant was concentrated under reduced pressure at 70°C, dried and pulverized to obtain 465 g of ...

Embodiment 3

[0034] The ultra-high pressure extraction method of embodiment 3 Periplaneta americana of the present invention

[0035] Weigh 1000g of Periplaneta americana, crush it into powder, add 8 times the amount (v / w) of 70% ethanol, pack it into a flexible container and seal it. Put it in an ultra-high pressure extractor, increase the pressure to 400MPa, pressurize 3 times, each time for 15min, the temperature is 60°C, release the pressure, open the cover to take a sample, and filter. The filtrate was concentrated under reduced pressure at 75°C until there was no ethanol smell, and the relative density was 1.10 (measured at 50°C). The concentrated solution was refrigerated at 10°C for 48 hours, and the upper layer of oil was absorbed with filter paper, and the lower layer was centrifuged in a high-speed refrigerated centrifuge. The temperature is 15°C, and the rotation speed is 10000r / min. The centrifuged supernatant was concentrated under reduced pressure at 75° C., dried, and pulv...

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Abstract

The invention discloses applications of periplaneta americana in preparing medicines used for treating bronchopneumonia and bronchitis. The medicines are used for treating diseases including chronic bronchopneumonia, Klebsiella bronchopneumonia, and nontypeable haemophilus influenzae bronchopneumonia, and the like. Active ingredients of periplaneta americana are extracted via ultrahigh pressure extraction; yield is high; operation is simple; and an obtained extract product can be used for treating bronchopneumonia, and clinical application prospect is promising.

Description

technical field [0001] The invention relates to the application of an extract of Periplaneta americana in the preparation of medicine for treating bronchopneumonia. Background technique [0002] Periplaneta americana (Periplaneta americana) is an insect belonging to the genus Periplaneta in the subclass Insecta Pterosae, Blatella order, Blattedae, commonly known as "cockroach". Taste: salty, cold; Cure: blood stasis syndrome with hard cold and heat, broken accumulation, closed throat, internal cold without seeds". In recent years, as our country attaches great importance to the research and development of traditional Chinese medicine resources, some scholars have made further research and made gratifying achievements. Its main pharmacological effects are reflected in eliminating inflammation and edema, promoting wound healing and regulating immunity. The active ingredients of Periplaneta americana include amino acids, peptides, ketones and trace elements. [0003] Broncho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P11/00A61P31/04
Inventor 陈光健
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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