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Compound montmorillonite lysozyme powder as well as preparation method and application thereof

The technology of lysozyme powder and montmorillonite, which is applied in the field of medicine, can solve the problems of unsatisfactory treatment effect, difficult healing of wound surface, harm of ulcer surface, etc., and achieve the effects of promoting rapid healing, promoting ulcer healing and prolonging drug effect.

Inactive Publication Date: 2015-07-15
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the raw materials, excipients, and production conditions used in the preparation are not sterilized or the sterilization method is improper, it is easy to cause secondary infection clinically, making it more difficult to heal the wound surface, and the treatment effect is very unsatisfactory or cause greater damage to the ulcer surface. harm
In addition, compound montmorillonite lysozyme powder medicines specially used for the treatment of skin ulcers (bedsores, scald ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, and postoperative ulcers), especially compound montmorillonite lysozyme powders Preparations have not been reported yet

Method used

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  • Compound montmorillonite lysozyme powder as well as preparation method and application thereof
  • Compound montmorillonite lysozyme powder as well as preparation method and application thereof
  • Compound montmorillonite lysozyme powder as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0183] Example 1. Preparation and preparation of compound montmorillonite lysozyme powder

[0184] 1. The proportion of raw and auxiliary materials (w / w):

[0185] Montmorillonite 50 parts

[0186] Lysozyme 5 parts

[0187] 20 parts of hydroxypropyl cellulose

[0188] 2. Prepare as follows:

[0189] (1) Weigh each component of montmorillonite, lysozyme, and hydroxypropyl cellulose according to the ratio for use;

[0190] (2) Put the montmorillonite into a dry heat sterilization cabinet, sterilize at a temperature of 250°C, and sterilize for 120 minutes, and then lower to room temperature for later use;

[0191] (3) Put the hydroxypropyl cellulose in an ethylene oxide sterilizer for sterilization, at a temperature of 40°C, a pressure of 50Kpa, and a sterilization time of 3h, ready for use;

[0192] (4) Put the lysozyme into an ultraviolet disinfection cabinet for sterilization, the ultraviolet band is controlled in the range of UV-C 253nm, and the sterilization time is 20min, ready for use; ...

Embodiment 2

[0199] Example 2. Preparation and preparation of compound montmorillonite lysozyme powder

[0200] 1. The ratio of raw material and auxiliary materials (w / w):

[0201] Montmorillonite 100 parts

[0202] Lysozyme 8 parts

[0203] Hydroxypropyl cellulose 40 parts

[0204] 2. Prepare as follows:

[0205] (1) Weigh each component of montmorillonite, lysozyme, and hydroxypropyl cellulose according to the ratio for use;

[0206] (2) Put the montmorillonite in a dry heat sterilization cabinet, sterilize at a temperature of 350°C, and sterilize for 120 minutes, and then lower to room temperature for later use;

[0207] (3) Put the hydroxypropyl cellulose in an ethylene oxide sterilizer for sterilization, at a temperature of 60°C, a pressure of 35Kpa, and a sterilization time of 6h, for standby;

[0208] (4) Put the lysozyme into an ultraviolet disinfection cabinet for sterilization, the ultraviolet band is controlled in the range of UV-C 270nm, and the sterilization time is 30min, ready for use;

[...

Embodiment 3

[0215] Example 3. Preparation and preparation of compound montmorillonite lysozyme powder

[0216] 1. The ratio of raw material and auxiliary materials (w / w):

[0217] 75 parts of montmorillonite

[0218] Lysozyme 7 parts

[0219] 30 parts of hydroxypropyl cellulose

[0220] 2. Prepare as follows:

[0221] (1) Weigh each component of montmorillonite, lysozyme, and hydroxypropyl cellulose according to the ratio for use;

[0222] (2) Put the montmorillonite into a dry heat sterilizer, sterilize at a temperature of 300°C, and sterilize for 120 minutes, and then lower to room temperature for later use;

[0223] (3) Put the hydroxypropyl cellulose in an ethylene oxide sterilizer for sterilization, at a temperature of 50°C, a pressure of 40Kpa, and a sterilization time of 4h, ready for use;

[0224] (4) Put the lysozyme into an ultraviolet disinfection cabinet for sterilization, the ultraviolet band is controlled in the range of UV-C 260nm, and the sterilization time is 30min, for standby;

[0225...

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PUM

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Abstract

The invention relates to compound montmorillonite lysozyme powder for treating skin ulcer, a preparation method and application thereof. The compound montmorillonite lysozyme powder is prepared from the following raw materials in parts by weight: 50-120 parts of montmorillonite, 5-10 parts of lysozyme, and 20-50 parts of hydroxy propyl cellulose. According to the invention, the montmorillonite and the lysozyme are used as the effective components and the pharmaceutic adjuvant of the compound montmorillonite lysozyme powder disclosed by the invention; and the compound montmorillonite lysozyme powder is prepared into a drug through the processes, such as a montmorillonite dry heat sterilization process, a lysozyme ultraviolet sterilization process and a hydroxy propyl cellulose ethylene oxide process. The invention further provides application of the preparation in preparation of a drug for treating skin ulcer. Due to drug delivery for skin external use, the compound montmorillonite lysozyme powder has better effects on skin ulcer in different periods.

Description

Technical field [0001] The invention relates to a compound montmorillonite lysozyme powder for treating skin ulcers and a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Chronic skin ulcers, also known as refractory ulcers, are more common in the elderly, especially in the elderly with diabetes, vasculitis and venous reflux disorder of the lower extremities. With the aging trend of the population and the increasing incidence of diabetes and cardiovascular diseases, the incidence of chronic skin ulcers has also increased. Clinically, skin ulcers caused by arteriosclerosis obliterans, diabetes, cardiovascular and cerebrovascular diseases and trauma are increasing, accounting for about 3% of surgical hospitalized patients. Because skin ulcers occur on the body surface, they have the characteristics of long course of disease, great influence on appearance and many complications, which have caused great harm to...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K9/14A61K47/38A61P17/02A61K33/06
Inventor 乔敏
Owner SHANDONG SBOND PHARMA
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