Ultrasound contrast medium in which nanoparticles containing drug are combined, and preparation method therefor

A nanoparticle and manufacturing method technology, applied in the direction of medical preparations containing active ingredients, preparation of X-ray contrast agents, medical preparations of non-active ingredients, etc., can solve problems such as improving the therapeutic effect, difficult to load drugs, and narrow space , to achieve the effect of improving drug delivery ability

Active Publication Date: 2015-07-01
IMGT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structure of ultrasound contrast media used for ultrasound diagnosis generally has a very narrow space for containing drugs, and it is difficult to load sufficient drugs. Therefore, there is a problem that it is difficult to drastically improve the therapeutic effect.

Method used

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  • Ultrasound contrast medium in which nanoparticles containing drug are combined, and preparation method therefor
  • Ultrasound contrast medium in which nanoparticles containing drug are combined, and preparation method therefor
  • Ultrasound contrast medium in which nanoparticles containing drug are combined, and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] produce microbubbles

[0052] Distearoylphosphatidylcholine (1,2-distearoyl-sn-glycero-3-phosphocholine, DSPC), DSPE-PEG2000-NHS (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine- n-[poly(ethyleneglycol)] 2000 -N-hydroxysuccinimide) and polyoxyethylene 40 stearate (Polyoxyethylene 40stearate, POE40s) as an emulsifier were mixed at a molar ratio of 8:1:1 and dissolved in chloroform, and then used The chloroform was completely evaporated by a rotary evaporator to form a lipid film.

[0053] Next, distilled water, propylene glycol (propylene glycol), and glycerin (glycerin) were mixed at 8:1:1, and this was added to the lipid film. Melt the lipid while maintaining the temperature at 55-60. Put SF6 or C3F8 gas into the container containing the mixed liquid and fill it to 200kPa, then make microbubbles by sonication and mechanical agitation.

[0054] Fabrication of Nanoparticles (HSA-NPs)

[0055]After dissolving human serum albumin (Human Serum Albumin: HSA)-40 mg in ...

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Abstract

The present invention relates to an ultrasound contrast medium in which nanoparticles are combined having increased drug delivery capacity and enhanced drug penetration effects, and a preparation method therefor. The ultrasound contrast medium, according to the present invention, comprises drug-loaded nanoparticles combined on the surface thereof, and thus has improved drug delivery capacity and nanoparticle penetration. In addition, the present invention prepares nanoparticles using a cancer target-specific protein, thereby allowing selective diagnosis and treatment of cancer to be simultaneously carried out.

Description

technical field [0001] The present invention relates to an ultrasonic contrast agent combined with nanoparticles containing drugs and a manufacturing method thereof (ULTRASOUND CONTRAST MEDIUM IN WHICH NANOPARTICLES CONTAINING DRUG ARE COMBINED, AND PREPARATION METHOD THEREFOR). In more detail, the present invention relates to an ultrasonic contrast agent combined with nanoparticles Ultrasonic contrast agent and its manufacturing method, the nano particles improve drug delivery ability and drug penetration effect. Background technique [0002] Ultrasonic imaging devices can diagnose in real time, so they have the best advantage of quickly deriving results, and unlike MRI and CT, they are simple in structure and low in cost. Ultrasonic waves are applied after the ultrasound contrast agent is injected, and the ultrasonic waves are reflected by the microbubbles in the contrast agent, so that the images of internal organs can be displayed more clearly. The ultrasound contrast a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K49/08A61K9/16A61P35/00
CPCA61K9/127A61K31/704A61K31/337A61K47/4893A61K47/48884A61K47/48869A61K9/5169A61K49/223A61K49/227A61K9/1271A61K47/6925A61K47/6929A61K47/6941A61P35/00
Inventor 金贤哲文贤权宋泰景章镇浩刘扬穆
Owner IMGT
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