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Compound suspended ear drops for treating auditory canal inflammation of dogs

A technology for ear canal inflammation and ear drops, applied in the directions of anti-inflammatory agents, liquid delivery, pharmaceutical formulations, etc., can solve the problems of unsuitability for industrial scale production, complex process, unpredictable stability of ear drops, etc., and achieve good clinical results. Application effect, simple process, good stability and performance

Inactive Publication Date: 2015-07-01
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The patent (CN101590067A, published on December 2, 2009) provides a method for preparing compound ear drops involving ivermectin. The ear drops prepared by this method have better clinical effects, but the formula does not involve The stability of the ear drops is unpredictable. At the same time, the preparation process needs to be filtered through a microporous membrane. The process is relatively complicated and is not suitable for industrial scale production.

Method used

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  • Compound suspended ear drops for treating auditory canal inflammation of dogs
  • Compound suspended ear drops for treating auditory canal inflammation of dogs
  • Compound suspended ear drops for treating auditory canal inflammation of dogs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: suspension type ear drops of clotrimazole, betamethasone valerate and gentamicin sulfate:

[0020]

[0021]

[0022] Preparation method:

[0023] (1) Weigh the above-mentioned liquid paraffin and Tween 80, stir and heat to 110°C, then cool down to about 50°C;

[0024] (2) Add the above-mentioned clotrimazole, betamethasone valerate, gentamicin sulfate and citric acid into the mixture of (1) to obtain the A mixture;

[0025] (3) Pass the above mixture A through a tissue smasher (DS-200, 8000r / min) for 5 minutes, pass it through a high-pressure homogenizer twice under a pressure of 800bar, and filter under reduced pressure to remove air bubbles to obtain Kemou Suspension ear drops of azole, betamethasone valerate and gentamicin sulfate.

Embodiment 2

[0026] Embodiment 2: suspension type ear drops of clotrimazole, betamethasone valerate and gentamicin sulfate:

[0027]

[0028] Preparation method:

[0029] (1) Weigh the liquid paraffin and soybean lecithin of the above weight, stir and heat to 110°C, stop heating, and cool down to 50°C;

[0030] (2) adding the above-mentioned clotrimazole, betamethasone valerate, gentamicin sulfate and ascorbic acid into the mixture of (1) to obtain the mixture A;

[0031] (3) Pass the above mixture A through a tissue smasher (DS-200, 8000r / min) for 5 minutes, pass it through a high-pressure homogenizer twice under a pressure of 800bar, and filter under reduced pressure to remove air bubbles to obtain Kemou Suspension ear drops of azole, betamethasone valerate and gentamicin sulfate.

Embodiment 3

[0032] Embodiment 3: suspension type ear drops of clotrimazole, betamethasone valerate and gentamicin sulfate:

[0033]

[0034]

[0035] Preparation method:

[0036] (1) Weigh the Tween 80 and soybean oil of the above weight, stir and heat to 110°C, then cool down to 50°C;

[0037] (2) Add the above-mentioned clotrimazole, betamethasone valerate, gentamicin sulfate and citric acid into the mixture of (1) to obtain the A mixture;

[0038] (3) Pass the above mixture A through a tissue smasher (DS-200, 8000r / min) for 5 minutes, pass it through a high-pressure homogenizer twice under a pressure of 800bar, and filter under reduced pressure to remove air bubbles to obtain Kemou Suspension ear drops of azole, betamethasone valerate and gentamicin sulfate.

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Abstract

The invention relates to a preparation method for compound clotrimazole, betamethasone valerate and gentamicin sulphate suspended ear drops for treating ear inflammation of dogs. According to the preparation method, the above several medicines are stably and uniformly stored in oily ear drops and not precipitated in several hours, with stable effective ingredient contents through a special process treatment. The production process disclosed by the invention is simpler and more convenient to operate, easily available in raw materials, beneficial to industrialized production, good in stability, convenient to store and transport, and remarkable in clinic treatment effect, as well has a large-scale production and clinic application advantage.

Description

technical field [0001] The invention relates to a compound suspension ear drop for treating inflammation of the canine ear canal, in particular to a suspension ear drop containing clotrimazole, betamethasone valerate and gentamicin sulfate and its Preparation. Background technique [0002] With the improvement of people's living standards and the change of life patterns in our country, pets, as companion animals of human beings, are increasing in number, especially in large and medium-sized cities. At the same time, the prevention and treatment of pet diseases are increasingly valued by pet owners. Otitis externa is an acute and chronic common ear canal disease caused by bacteria and fungi. After pets suffer from otitis externa, the clinical symptoms often manifest as itching, erythema of the auricle and ear canal, excessive ear secretions (cerumen) and peculiar smell. Because of itching, sick dogs and cats often show behaviors such as shaking their heads, scratching thei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K9/10A61P27/16A61P29/00A61K31/4174A61K31/573
Inventor 赵宝国刘桂兰王小武
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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