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A kind of compound and its preparation method and application

A technology for compounds and concentrates, applied in the field of compounds and their preparation, can solve problems such as systematic research that has not been reported

Active Publication Date: 2016-08-17
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total phenolic fraction of dragon's blood is the main component of dragon's blood, but no systematic research on its material basis has been reported

Method used

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  • A kind of compound and its preparation method and application
  • A kind of compound and its preparation method and application
  • A kind of compound and its preparation method and application

Examples

Experimental program
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preparation example Construction

[0039] The present invention also provides a method for preparing the compound of formula (I), including:

[0040] 1) Perform chromatographic separation of Dragon's blood through a macroporous adsorption resin column, eluting with an aqueous solution of alcohol with a first mass concentration and an aqueous solution of alcohol with a second mass concentration, and collect the elution parts of the aqueous solution of alcohol with a second mass concentration Eluent,

[0041] The alcohol is a C1-C6 alcohol,

[0042] The first mass concentration alcohol aqueous solution is 20% to 60% alcohol aqueous solution,

[0043] The second mass concentration of the alcohol aqueous solution is an 80% to 98% alcohol aqueous solution;

[0044] 2) Concentrate the eluate obtained in step 1) to obtain a concentrate of the second mass concentration of the eluted portion of the alcohol aqueous solution;

[0045] 3) Chromatographic separation of the concentrate obtained in step 2), and the collection contains ...

Embodiment 1

[0068] 10g of the raw material of Longxuetongluo Capsules was dissolved in 40% ethanol and loaded, separated by HP-20 macroporous adsorption resin chromatographic column, and eluted with 2L 40% alcohol aqueous solution, 2L 95% alcohol aqueous solution, and collected 95 The obtained eluate is eluted with a% alcohol aqueous solution, and the recovered eluate is concentrated to dryness to obtain a concentrate (extract I).

[0069] The extract I was dissolved in a small amount of methanol for LH-20 gel separation, the eluent was methanol, and 1 part (2mL) was automatically received every three minutes. A total of 30 components were collected, and the components 11-14 were combined and recorded as the group Part A is concentrated and dried.

[0070] Component A is dissolved in a small amount of methanol and then separated by LH-20 gel again. The eluent is methanol. One part (2mL) is automatically received every three minutes. A total of 30 components are collected, and each component A-...

Embodiment 2

[0075] 10g of dragon's blood total phenols were dissolved in 40% ethanol and loaded on HP-20 macroporous adsorption resin chromatographic column, followed by 1.5L 20% methanol aqueous solution, 1.5L 40% methanol aqueous solution, 1.5L 60% methanol aqueous solution, 1L 90 Elute with 5% methanol aqueous solution, collect the eluate obtained from 90% alcohol aqueous solution, and recover the eluate after concentrating to dryness to obtain a concentrate (Extract I).

[0076] The extract I was dissolved with a small amount of methanol to separate silica gel H, and the eluent was 500mL with chloroform: methanol volume ratio 15:1, 500mL 10:1, 500mL 5:1, 300mL 2:1, The TLC dot plate ultraviolet showed that the developing agent was chloroform: methanol 5:1, and a total of five components were collected and concentrated. Marked as FrI-1, FrI-2, FrI-3, FrI-4, FrI-5.

[0077] Dissolve the concentrated FrI-4 with a small amount of methanol for separation on silica gel H. The eluent is a mixed ...

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Abstract

The invention provides a compound, as well as a preparation method and an application thereof; the structure of the compound provided by the invention is presented by the formula (I); the compound has the in-vitro inhibiting effect to lipase; and furthermore, animal experiments show that the compound provided by the invention has the effect of reducing blood fat.

Description

Technical field [0001] The invention relates to the field of medical technology, in particular to a compound and its preparation method and application. Background technique [0002] Dragon's blood is a resin extracted from the lipid-containing xylem of the dracaena genus Dracaena in the Liliaceae family. Its pharmacological effects are mainly for promoting blood circulation and removing blood stasis, hemostasis, anti-inflammatory and analgesic, etc. It is clinically used to treat ischemic heart disease and uterus. Fibroids, upper gastrointestinal bleeding and other diseases. [0003] Hyperlipidemia and lipid metabolism disorders are the main risk factors for atherosclerosis (AS). Atherosclerosis refers to the deposition and necrosis of lipids, carbohydrates and blood components in the aorta and middle arteries (such as brain, kidney, coronary artery intima) to form atheroma, smooth muscle cells and collagen fibers proliferate, calcify and harden, and form thrombus. Causes lumen ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/58A61K31/353A61P3/06A61P3/04
CPCC07D311/58
Inventor 萧伟孙林孟兆青李孟璇刘丽萍杨彪黄文哲丁岗王振中
Owner JIANGSU KANION PHARMA CO LTD
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