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Blood lipid-lowering active fraction of black fungus and its preparation method and application

The technology of active parts and black fungus is applied in the field of preparation of blood lipid-lowering active parts in black fungus, can solve the problems of easy rebound, obvious toxic and side reactions, and high price, and achieves the effects of improved effect, clear chemical composition, and increased content.

Active Publication Date: 2021-07-20
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the above chemical drugs have the disadvantages of high price, obvious toxic and side effects, and easy rebound after drug withdrawal; therefore, seeking new drug sources has become one of the research hotspots in the medical field

Method used

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  • Blood lipid-lowering active fraction of black fungus and its preparation method and application
  • Blood lipid-lowering active fraction of black fungus and its preparation method and application
  • Blood lipid-lowering active fraction of black fungus and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A black fungus hypolipidemic active part, by weight, the total triterpene content of the active part is 15.6-35.9%, the total polyphenol content is 28.4-53.6%, and the weight ratio of triterpenoids to polyphenols is 1: (1.5-2.9).

[0034] An application of the active site in the preparation of blood lipid-lowering drugs.

[0035] A method for preparing the blood lipid-lowering active part of black fungus, comprising the following steps:

[0036] (1) Enzymolysis: Take 50g of black fungus, dry it at 50 degrees, and crush it. 100U compound enzyme solution of dry fungus powder, enzymatic hydrolysis at 40 degrees for 4 hours, heat inactivation of compound enzyme after enzymolysis;

[0037] (2) Extraction: add the above-mentioned enzymatic hydrolysis product into the extraction solution to be 60% ethanol aqueous solution, the dosage is 3 times the weight-volume ratio of the crude drug, the heating and reflux time is 4 hours, the extraction solution is refluxed and extracted...

Embodiment 2

[0042] A black fungus hypolipidemic active part, by weight, the total triterpene content of the active part is 15.6-35.9%, the total polyphenol content is 28.4-53.6%, and the weight ratio of triterpenoids to polyphenols is 1: (1.5-2.9).

[0043] An application of the active site in the preparation of blood lipid-lowering drugs.

[0044]A method for preparing the blood lipid-lowering active part of black fungus, comprising the following steps:

[0045] (1) Enzymolysis: Take 50g of black fungus, dry it at 50 degrees, and crush it. 100U compound enzyme solution of dry fungus powder, enzymatic hydrolysis at 40 degrees for 4 hours, heat inactivation of compound enzyme after enzymolysis;

[0046] (2) Extraction: the product after the above enzymolysis is extracted by adding 70% ethanol aqueous solution for ultrasonic extraction, the amount of 70% ethanol aqueous solution is 3 times the weight-volume ratio of the crude drug, the ultrasonic frequency is 300KHz, the ultrasonic temper...

Embodiment 3

[0052] A black fungus hypolipidemic active part, by weight, the total triterpene content of the active part is 16.7-21.1%, the total polyphenol content is 46.4-53.6%, and the weight ratio of triterpenoids and polyphenols is 1: (2.2-2.9).

[0053] An application of the active site in the preparation of blood lipid-lowering drugs.

[0054] A method for preparing the blood lipid-lowering active part of black fungus, comprising the following steps:

[0055] (1) Enzymolysis: Take 50g of black fungus, dry it at 50 degrees, and crush it. 100U compound enzyme solution of dry fungus powder, enzymatic hydrolysis at 40 degrees for 4 hours, heat inactivation of compound enzyme after enzymolysis;

[0056] (2) Extraction: add the above-mentioned enzymolysis product into the extraction solution to be 70% ethanol aqueous solution, the dosage is 5 times the weight-volume ratio of the crude drug, the heating and reflux time is 4 hours, the extraction solution is refluxed and extracted 3 times...

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Abstract

The present invention relates to a hypolipidemic active part of black fungus and a preparation method and application thereof. The black fungus obtains an active part with in vitro inhibitory effect on lipase through the preparation method provided by the invention, and animal experiments show that the The active part has the effect of lowering blood lipids, and the active part is determined to be 15.6-35.9% triterpenoids and 28.4-53.6% polyphenols, wherein the weight ratio of triterpenes and polyphenols is 1: (2.2- 2.9), the activity is higher. The active part of the black fungus can be used for preparing blood lipid-lowering drugs, and has a good development and application prospect. The invention also discloses the main component range of the active part of the black fungus for lowering blood lipids, which facilitates the improvement and control of quality standards during later development and application.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract with blood lipid-lowering activity, in particular to a preparation method and application of the blood-lipid-lowering active part in black fungus. Background technique [0002] Hyperlipidemia refers to blood cholesterol and / or triglycerides too high or high-density lipoprotein cholesterol too low, modern medicine is often referred to as dyslipidemia, also often referred to as hyperlipoproteinemia. Hyperlipidemia and lipid metabolism disorders are the main risk factors for atherosclerosis. The resulting cardiovascular and cerebrovascular diseases seriously endanger human health, and sometimes can lead to hypertension, diabetes, coronary heart disease and other diseases, causing renal failure, etc. . With the continuous improvement of living standards and changes in dietary structure, hyperlipidemia has shown a high incidence trend, and chronic medical diseases such as arteriosclerosis, cor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/07A61P3/06
Inventor 郭玉岩孙爽吕邵娃李永吉杨大宇
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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