Implant and method for producing an implant

An implant and tubular technology, applied in the field of implants, can solve problems such as non-retention, and achieve improved tissue processing effects

Active Publication Date: 2015-06-10
威德瑞真有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, SIS does not preserve the original vascular supply to the tissue, resulting in limited perfusion

Method used

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  • Implant and method for producing an implant
  • Implant and method for producing an implant
  • Implant and method for producing an implant

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Experimental program
Comparison scheme
Effect test

Embodiment

[0089] All reagents were purchased from Sigma-Aldrich (UK) or Fisher Scientific (UK).

[0090] All animals were maintained and handled in accordance with the Animals Scientific Procedures Act 1986 (Animals Scientific Procedures Act 1986), and research was carried out through the following guidelines prescribed and licensed by the UK Home Office. Experiments were carried out using Large White Landrace crossbreed pigs. All animals were maintained under standard laboratory conditions and fed commercial pelleted chow.

[0091] 1. Preparation of decellularized scaffolds

[0092] (a) Harvested porcine intestinal tissue

[0093] After intravenous injection of heparin (7 000 U) in 60-65 kg English Large White Landrace crossbred pigs, a midline incision was made and the ileal part was separated from its connected vascular supply approximately 20-30 cm long. Dissect the remaining lymph nodes of the mesentery; keep the entire sample leak-proof; tie and separate the distal end of t...

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PUM

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Abstract

A method for producing an implant from intestinal tissue 101, the intestinal tissue comprises a tubular segment 103 of intestine with at least part of its associated vasculature 102 intact, the method comprises: perfusing the vasculature 102 through a vessel thereof with at least one decellularising medium, and separately perfusing the tubular segment 103 of intestine through its lumen with at least one decellularising medium. The tubular segment 103 of intestine may be harvested from a human or non-human mammal such that at least part of the associated vasculature 102 is retained intact. Also claimed is a substantially decellularised implant derived from intestinal tissue 101 comprises a tubular component 103 and a vascular component 102, wherein a luminal surface of the vascular component 102 comprises the internal elastic lamella which displays original elastin fibre architecture and molecular ultrastructure of the vasculature from which it is derived. The apparatus for processing the intestinal implant 101 comprises a first perfusion circuit for perfusing the vasculature 102 with at least one decellularising medium, and a second perfusion circuit for separately perfusing the tubular segment 103 of intestine through its lumen with at least one decellularising medium.

Description

technical field [0001] The present invention relates to implants and methods for producing implants. The invention is particularly useful in the production of intestinal-derived implants. Background technique [0002] Implants comprising biologically derived scaffolds have become an important option for tissue / organ repair and regeneration in the treatment of various diseases and conditions. A continuing major obstacle is the requirement for a functional blood supply of the implanted stent. [0003] Patients with Short Bowel Syndrome (SBS) lack more than half of their small intestine, which can result from numerous disorders and often results in surgical resection. A suitable implant would be useful in the treatment of SBS. Intestinal diseases such as Crohn's disease in adults and necrotizing enterocolitis in infants are disorders that can lead to short bowel syndrome (SBS) and subsequent malabsorption of nutrients requiring intestinal transplantation. This is a major cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36
CPCA61L27/3629A61L27/3691A61P1/04A61P41/00A61B17/1114A61F2/062A61F2/064A61L27/3604A61F2/04A61F2002/045
Inventor 保罗·大卫·西本斯塔赫拉·伊克巴尔·安萨里
Owner 威德瑞真有限公司
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