Application of Cornus officinalis Total Saponins in the Preparation of Drugs for Prevention and Treatment of Diabetic Complications

A technology of Cornus officinalis and total saponins, which is applied in the field of biomedicine, can solve the problems of large side effects and single hypoglycemic approach of western medicine, and achieve the effect of lowering blood sugar, considerable development and application value, and no toxic and side effects

Active Publication Date: 2019-10-08
SHAANXI NORMAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The object of the present invention is to provide the application of total saponins of Cornus officinalis in anti-diabetes, the main active ingredient total saponins of Cornus officinalis extracted from Cornus officinalis can be used to prepare medicines for treating diabetes, solve the problems of single hypoglycemic approach and large side effects of western medicine, and provide anti-diabetic drugs for the active ingredients of traditional Chinese medicine. sugar provides evidence

Method used

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  • Application of Cornus officinalis Total Saponins in the Preparation of Drugs for Prevention and Treatment of Diabetic Complications
  • Application of Cornus officinalis Total Saponins in the Preparation of Drugs for Prevention and Treatment of Diabetic Complications
  • Application of Cornus officinalis Total Saponins in the Preparation of Drugs for Prevention and Treatment of Diabetic Complications

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Embodiment Construction

[0028] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0029] 1. Experimental materials

[0030] Cornus officinalis was collected in Foping, Shaanxi in October 2013, and was identified as Cornus officinalis Sieb.et Zucc. by Professor Xiao Yaping of Shaanxi Normal University.

[0031] Take the dried pulp of Cornus officinalis that has been pitted, crush it, and pass it through a 40-mesh sieve for later use. Add 21 times of 70% ethanol solution → extract at microwave power 417W, ultrasonic power 369W for 5 minutes → filter with suction, evaporate ethanol, extract with water-saturated n-butanol for 3 times → evaporate to dryness under reduced pressure, redissolve in distilled water → HPD- 300-type macroporous resin purification (adsorption time 3h, sample concentration 3.5mg mL-1, eluent concentration 50% ethanol, elution volume 8BV) → eluate conce...

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Abstract

The invention discloses application of cornus officinalis total saponins in cornus officinalis to diabetes mellitus resistance and belongs to the technical field of biological medicine. The cornus officinalis total saponins which are main active ingredients extracted from the cornus officinalis can be used for preparing medicine for treating diabetes mellitus, the problems that western medicine has a single blood sugar reducing way and large side effects are solved, and a basis is provided for reducing blood sugar through active ingredients of Chinese medicine. The cornus officinalis total saponins are safer, more effective, mild, durable and free of toxic and side effects, has a multi-effect, multi-target and multifunctional action mechanism, has the effect of reducing blood sugar and also plays an important role in preventing and treating diabetic complications. Thus, the cornus officinalis total saponins have considerable development and application value in the aspect of improving diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the antidiabetic application of cornus officinalis total saponins. Background technique [0002] Diabetes Mellitus (DM) is an endocrine and metabolic disease characterized by hyperglycemia caused by absolute or relative insufficient secretion of insulin. The incidence of DM is increasing year by year worldwide. It is the third largest non-communicable disease after cancer and malignant tumors, seriously affecting human health and quality of life. Nowadays, the proportion of type 2 diabetes in diabetic patients in our country is increasing day by day, reaching more than 93.7%. The existing chemical drugs for diabetes all have the disadvantages of large toxic and side effects and single target effect, while the natural plant active ingredients have the advantages of small toxic and side effects, multi-site effects, and low price, which have become the first choice ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/40A61P3/10A61P3/06A61P1/16A61P29/00
Inventor 康杰芳王红菊杨宁白嫄王韶君王喆之
Owner SHAANXI NORMAL UNIV
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