Application of radix rehmanniae leaf extract in preparation of blood glucose-reducing medicines
A technology of rehmannia root and its extract, which is applied in the field of medicine, can solve problems such as the hypoglycemic effect of rehmannia rehmannia leaves, and achieve the effect of rich raw materials, easy operation, and simple preparation method
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Embodiment 1
[0015] An application of rehmannia root extract in the preparation of hypoglycemic drugs. The rehmannia leaf extract is obtained by taking 500g of rehmannia leaf, washing away the sediment, cutting into wide strips, ventilating and drying below 40°C, and placing it in extraction equipment (such as In the extraction tank), add 10 times the weight of Rehmannia glutinosa leaves for reflux extraction twice, each time for 1h, filter, combine the filtrate (ie extract), and put the filtrate into a rotary evaporator (Shanghai Yarong Biochemical Instrument Factory, model: RE52-99), depressurize to -0.1MPa, concentrate at 55°C to a concentrated solution equivalent to 1g / ml crude drug content, add ethanol with a mass concentration of 95% to make the alcohol concentration reach 70%, and stand at 4°C for 24h , take the supernatant, concentrate under reduced pressure, and concentrate the supernatant under reduced pressure to 55°C, which is equivalent to the concentrated solution containing c...
Embodiment 2
[0017] An application of rehmannia rehmannia leaf extract in the preparation of hypoglycemic drugs. The rehmannia rehmannia leaf extract is obtained by taking 500g of rehmannia rehmannia leaf, washing away the sediment, cutting into wide shreds, ventilating and drying at a temperature below 40°C, and placing it in an extraction device. Each time add 12 times the weight of rehmannia leaves, reflux and extract twice, each time for 1h, filter, combine the filtrate, put the filtrate in a rotary evaporator, reduce the pressure to -0.1MPa, and concentrate at 55°C until the crude drug content is equivalent to 2g / ml of concentrated solution, add ethanol with a mass concentration of 95% to make the alcohol concentration reach 80%, let stand at 4°C for 24h to precipitate, take the supernatant, concentrate under reduced pressure, and concentrate the supernatant under reduced pressure to 55°C, which is equivalent to containing crude drug The concentrated solution of 2.5 mg / ml was separate...
Embodiment 3
[0019] An application of rehmannia rehmannia leaf extract in the preparation of hypoglycemic drugs. The rehmannia rehmannia leaf extract is obtained by taking 500g of rehmannia rehmannia leaf, washing away the sediment, cutting into wide shreds, ventilating and drying at a temperature below 40°C, and placing it in an extraction device. Each time add 11 times the weight of rehmannia leaves, reflux extraction twice, each time for 1.5h, filter, combine the filtrate, put the filtrate in a rotary evaporator, reduce the pressure to -0.1MPa, and concentrate at 55°C to the equivalent crude drug content 0.5g / ml concentrated solution, add ethanol with a mass concentration of 95% to make the alcohol concentration reach 60%, let it stand at 4°C for 24h, take the supernatant, concentrate under reduced pressure, and concentrate the supernatant under reduced pressure to 55°C, which is equivalent to containing The concentrated solution of crude drug 4.5mg / ml is separated and purified by H103 r...
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