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Coptis donkey-hide gelatin composition for treating Sjögren's syndrome and its application

A technology of Sjögren's syndrome and composition, which is applied in the field of Coptis donkey-hide gelatin composition for the treatment of Sjögren's syndrome, can solve the problems of restricting the clinical curative effect of Sjögren's syndrome, restricting the unity of disease understanding and thinking, and the actual curative effect is not very clear. Achieve the effect of improving mental state and immune function, satisfying clinical effect, and safe clinical use

Active Publication Date: 2017-11-14
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of traditional Chinese medicine to treat Sjögren's syndrome has achieved certain curative effects. However, in the process of clinical diagnosis and treatment, most modern doctors are mostly limited to clinical observation and experience introduction. The diagnosis and treatment standards are very random, and the actual curative effect is not very clear. Clinicians It is limited to the individual understanding of the disease, which greatly limits the clinical curative effect of Sjogren's syndrome, and also limits the unity of understanding and thinking of the disease itself; currently there is no traditional Chinese medicine preparation for the treatment of Sjogren's syndrome with a more accurate curative effect on the market listing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of capsule

[0033] (1) Weigh each raw material according to the following weight: Coptis chinensis 800g, donkey-hide gelatin 900g, white peony root 600g, scutellaria baicalensis 300g, jujube seed

[0034] 600g, 200g cinnamon, 600g acacia bark;

[0035] (2) Extract the volatile oil from cinnamon, wrap the volatile oil and crush it, set aside;

[0036] (3) Extract the cinnamon dregs after extracting the volatile oil with water for two times, add 2 times the weight of water for the first time, decoct for 3 hours, add 4 times the weight of water for the second time, and decoct for 1 hour; Combine the boiled liquids, filter, and concentrate the filtrate to a relative density of 1.30-1.35 (55°C) to clear the paste; combine two clear pastes, spray dry, and set aside;

[0037] (4) Extract Coptidis Rhizoma, Radix Paeoniae Alba and Jujube Semen with 85% ethanol, spray-dry the extract, and set aside;

[0038] (5) Grind donkey-hide gelatin and mix ...

Embodiment 2

[0039] Embodiment 2: the preparation of capsule

[0040] Prescription Composition:

[0041] Coptidis 280g Donkey-hide gelatin 315g White peony root 210g Scutellaria baicalensis 105g

[0042] Suanzaoren (stir-fried) 210g cinnamon 70g Albizia juniper skin 210g

[0043] Preparation Process:

[0044] (1) Coptis chinensis, Radix Paeoniae Alba, Suanzaoren plus 70% ethanol, extracted 6 times for 3 times, each time for 1.5 hours, filtered, the filtrate recovered ethanol, concentrated to a relative density of 1.08-1.10 (60°C), and spray-dried. fine powder for use;

[0045] (2) Add 12 times the amount of water to cinnamon, soak for 3 hours, extract the volatile oil for 3.5 hours, store the volatile oil and water extract separately for later use, and save the dregs for later use; add 10 times the amount of β-cyclodextrin to the cinnamon volatile oil and then add β-cyclodextrin Mix 20% ethanol with 3 times the amount of dextrin, grind it with a colloid mill for 15 minutes, refrigerate...

Embodiment 3

[0048] Embodiment 3: the preparation of powder

[0049] Weigh each raw material according to the following weight: Coptidis 600g, donkey-hide gelatin 700g, white peony 400g, scutellaria baicalensis 100g, jujube seed 400g, cinnamon 50g, acacia bark 400g; crush the above-mentioned raw materials and pass through a 80-mesh sieve to obtain the product.

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Abstract

The invention discloses a Coptis donkey-hide gelatin composition for treating Sjögren's syndrome and an application thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition of the invention comprises the following raw materials: Coptidis Rhizoma, Ejiao, Radix Paeoniae Alba, Radix Scutellariae, Jujube Seed, Cinnamon and Cortex Albiziae. The prescription of the present invention has the merits of nourishing yin and moistening dryness, clearing away heat and detoxification, promoting blood circulation and removing blood stasis, and at the same time, it has a relatively obvious therapeutic effect on Sjögren's syndrome, with a cure rate of 62.9% and a total effective rate of 95.2%. side effects etc. The traditional Chinese medicine composition of the present invention is safe in clinical use, and the patient does not have any adverse reaction after use, and can effectively improve the patient's mental state and immune function, and does not produce any dependence reaction after the drug of the present invention is stopped.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a composition of coptis donkey-hide gelatin for treating Sjögren's syndrome and its application. Background technique [0002] Sjögren's syndrome (Sjogren Syndrome, SS) is a chronic autoimmune disease that invades exocrine glands, especially salivary glands and lacrimal glands. Its immune inflammatory response is mainly manifested in the epithelial cells of exocrine glands, so it is also called Autoimmune exocrine gland epithelial cell inflammation or autoimmune exocrine disease. The main clinical manifestations are keratoconjunctivitis sicca, xerostomia, and other important internal organs such as lung, liver, pancreas, kidney, blood system, and nerve complex clinical manifestations. The onset of this disease is often hidden, and the clinical manifestations are diverse. The main manifestations are related to glandular dysfunction. In recent years...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61P37/02A61K35/36
Inventor 张淹周祥山田守生王春艳李士栋
Owner SHAN DONG DONG E E JIAO
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