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A kind of preparation method of isatidis film-coated tablet

A technology of film coating and Radix Radix is ​​applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of splits, thick coating layers, and high labor intensity, and achieve good results. Adhesive, good bleeding, good hydrophilic effect

Active Publication Date: 2018-01-23
广西世彪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories
Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of Radix Isatidis film-coated tablets:

[0027] 1) Raw material processing: Take 1000g of Radix isatidis, add water and ultrasonically extract twice, 30min each time, filter, combine the filtrate, concentrate the filtrate to 1000g, place it to room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, The filtrate is concentrated into a thick paste with a relative density of 1.15 (50℃);

[0028] 2) Tableting: adding 200g of starch and auxiliary materials to make granules and compressing into 1000 plain tablets;

[0029] 3) Coating: Put the plain tablets in the coating pan, use the rolling coating method, spray the coating liquid with a sprayer, keep the temperature in the pan at 35-37℃, and use continuous spraying addition method depending on the dryness of the surface Film coating liquid until the coating liquid is sprayed;

[0030] The amount of the coating liquid is 0.02%, and the coating liquid is composed of the foll...

Embodiment 2

[0036] A preparation method of Radix Isatidis film-coated tablets:

[0037] 1) Raw material processing: Take 1000g of Radix isatidis, add water and ultrasonically extract twice, 30min each time, filter, combine the filtrate, concentrate the filtrate to 1000g, place it to room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, The filtrate is concentrated into a thick paste with a relative density of 1.20 (50℃);

[0038] 2) Tableting: adding 200g of starch and auxiliary materials to make granules and compressing into 1000 plain tablets;

[0039] 3) Coating: Put the plain tablets in the coating pan, use the rolling coating method, spray the coating liquid with a sprayer, keep the temperature in the pan at 35-37℃, and use continuous spraying addition method depending on the dryness of the surface Film coating liquid until the coating liquid is sprayed;

[0040] The amount of the coating liquid is 0.05%, and the coating liquid is composed of the foll...

Embodiment 3

[0046] A preparation method of Radix Isatidis film-coated tablets:

[0047] 1) Raw material processing: Take 1000g of Radix isatidis, add water and ultrasonically extract twice, 30min each time, filter, combine the filtrate, concentrate the filtrate to 1000g, place it to room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, The filtrate is concentrated into a thick paste with a relative density of 1.18 (50℃);

[0048] 2) Tableting: adding 200g of starch and auxiliary materials to make granules and compressing into 1000 plain tablets;

[0049] 3) Coating: Put the plain tablets in the coating pan, use the rolling coating method, spray the coating liquid with a sprayer, keep the temperature in the pan at 35-37℃, and use intermittent spray addition method depending on the dryness of the surface Film coating liquid until the coating liquid is sprayed;

[0050] The amount of the coating liquid is 0.03%, and the coating liquid is composed of the follo...

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Abstract

The invention discloses a preparation method of Radix isatidis film-coated tablet, comprising: 1) raw material processing: take 1000 parts by weight of Radix isatidis, add water and ultrasonically extract it twice, each time for 30 minutes, filter, combine the filtrate, concentrate the filtrate to 1000 parts by weight, Place it at room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, and concentrate the filtrate into a thick paste; 2) Compression: add 200 parts by weight of starch and auxiliary materials to make granules, and press into plain tablets; 3. ) coating: the plain tablet is put into the coating pan, and the rolling coating method is adopted until the coating solution is sprayed; the coating solution consumption is 0.02-0.05 parts by weight, and the coating solution consists of the following ingredients: Composition by weight ratio: 10-15% of carboxyethyl cellulose sodium, 10-15% of Luo Han Guo extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum, and the balance is pure water.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method of Isatis indigotica film-coated tablets. Background technique [0002] Film coating agent is a material for coating oral tablets. It usually consists of film-forming agent, plasticizer, auxiliary additives and coloring agent. When used, it is sprayed on water or a mixture of water and ethanol as the solvent. A smooth and uniform film coat can be formed on the surface of the drug core, so that the drug core can avoid the erosion of light, oxygen and moisture, beautify the appearance, improve the taste, and cover the smell. [0003] Film coating technology, the production process of wrapping tablets with a small amount of safe, non-toxic and stable physical and chemical properties of polymer materials. The safety of these polymer coating materials has long been widely recognized by countries around the world. Therefore, the development trend of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K36/195A61K36/315A61K47/46
Inventor 苏朝芳
Owner 广西世彪药业有限公司
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