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A preparation method of giant magnetically responsive drug-loaded vesicles with targeting function

A magnetically responsive and functional technology, applied in the field of preparation of drug-loaded vesicles, can solve the problems of poor cell killing selectivity, poor tumor tissue targeting, and large toxic and side effects, and achieves easy separation and purification, large drug-loading capacity, Simple to use effects

Active Publication Date: 2017-04-26
NINGBO FOCUS BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the shortcomings of the existing drugs for treating tumor diseases, such as large toxic and side effects, poor tumor tissue targeting and poor cell killing selectivity, and provide a giant magnetically responsive drug-loaded capsule with targeting function Bubble preparation method

Method used

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  • A preparation method of giant magnetically responsive drug-loaded vesicles with targeting function
  • A preparation method of giant magnetically responsive drug-loaded vesicles with targeting function
  • A preparation method of giant magnetically responsive drug-loaded vesicles with targeting function

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specific Embodiment approach 1

[0024] Embodiment 1: This embodiment is a method for preparing giant magnetically responsive drug-loaded vesicles with targeting function, which is specifically prepared according to the following steps:

[0025] 1. Preparation of phospholipid solution: Dissolve negatively charged phospholipids and neutral phospholipids in chloroform to obtain a phospholipid solution with a total phospholipid concentration of 1-20 mg / mL;

[0026] The total phospholipid concentration described in step 1 is that the mass ratio of negatively charged phospholipids and neutral phospholipids in the phospholipid solution of 1 to 20 mg / mL is (0.005 to 0.2): 1;

[0027] The negatively charged phospholipid described in step 1 is phosphatidylethanolamine phospholipid or fluorescent ethanolamine phospholipid;

[0028] The neutral phospholipid described in step 1 is a choline phospholipid;

[0029] 2. Apply the phospholipid solution with a total phospholipid concentration of 1 to 20 mg / mL obtained in step...

specific Embodiment approach 2

[0040] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the phosphatidylethanolamine phospholipid described in step 1 is dioleoylphosphatidylethanolamine; the fluorescently labeled ethanolamine phospholipid is TR-DHPE or NBD-PE. Others are the same as the first embodiment.

specific Embodiment approach 3

[0041] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the neutral phospholipid described in step one is choline phospholipid; Alkaline, egg yolk lecithin, dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method for giant magnetic-responsiveness medicine-carrying vesicles with a targeting function, and relates to a preparation method for medicine-carrying vesicles. The preparation method disclosed by the invention aims at solving the defects of high toxic and side effects, poor targeting effect on tumour tissues and poor selectivity on cell killing in the existing medicines for treating tumour diseases. The preparation method comprises the following steps: 1, preparing a phospholipid solution; 2, preparing ITO conductive glass with a surface covered with a phospholipid layer; 3, preparing a mixed solution of medicines and nano-particles; 4, assembling an airtight preparation device to react, so as to obtain the giant magnetic-responsiveness medicine-carrying vesicles with the targeting function. The giant magnetic-responsiveness medicine-carrying vesicles with the targeting function prepared by the preparation method disclosed by the invention have sizes up to 1-100mu m, high medicine-carrying amount, and the characteristics of being easy for carrier separation and purification, good in bio-security, high in release efficiency and controllable in release. The invention discloses a preparation method capable of obtaining giant magnetic-responsiveness medicine-carrying vesicles with a targeting function.

Description

technical field [0001] The invention relates to a method for preparing drug-loaded vesicles. Background technique [0002] Tumor disease is one of the diseases that seriously threaten human life and health. At present, comprehensive methods such as lesion resection, radiotherapy, chemotherapy and immunotherapy are mainly adopted. However, in the chemotherapy method, there are disadvantages such as high toxic and side effects of drugs, poor targeting of tumor tissues, and poor selectivity for killing cells. Therefore, it is particularly necessary to study the controlled release of targeted drug delivery carriers and drugs. [0003] Targeted drug delivery refers to the drug delivery method in which the carrier selectively accumulates and localizes the drug in the target tissue, target organ, target cell or intracellular structure through local administration or systemic blood circulation. Magnetic nanoparticles possess special superparamagnetic properties, which offer attra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K31/704A61K47/24A61K47/04A61P35/00
Inventor 韩晓军毕洪梅
Owner NINGBO FOCUS BIOMEDICAL TECH CO LTD
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