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Fimasartan dropping pill and preparation method thereof

A technology of Fimasartan and dropping pills is applied in the field of pharmaceutical preparations and their preparation, which can solve the problems of heavy and difficult taste, large dosage, slow onset of effect, etc., and achieves easy absorption, uniform drug dispersion, and accelerated dissolution and absorption. Effect

Inactive Publication Date: 2015-04-22
TIANJIN KANGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing fimasartan drugs are tablets, which have the disadvantages of large dosage, heavy taste, difficult to swallow, and slow onset of action. The process suitable for the new drug dosage form has also become an important issue of current research

Method used

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Examples

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preparation example Construction

[0016] The invention provides a Fimasartan dripping pill and a preparation method thereof. In the method, Fimasartan is used as the main raw material, and polyethylene glycol and other substrates are added in a certain proportion, and processed and prepared by specific processes and equipment. made. details as follows:

[0017] (1) Prescription: Fimasartan + matrix

[0018] Base: Contains polyethylene glycol (1500, 2000, 4000, 6000, 8000, 10000, 20000), polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, One or more components of stearic acid, sodium stearate, glycerin gelatin, glyceryl monostearate, shellac, polyoxyethylene monostearate, polyether.

[0019] The weight ratio of fimasartan to matrix is ​​1: (1-60).

[0020] Preparation process: the specific implementation steps are as follows:

[0021] The first step is to mix pramipexole with the matrix according to a certain ratio.

[0022] The second step is to use water bath, oil bath or ot...

Embodiment 1

[0036] Prescription: Fimasartan 0.5g; PEG4000 5g;

[0037] PEG8000 25g; 1000 capsules in total.

[0038] Preparation method: Mix Fimasartan, PEG4000, and PEG8000 evenly, heat in a water bath to make it completely melt, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip nozzle, and drop it into the In simethicone oil at -5°C, after molding, filter, separate, and wipe clean to obtain.

Embodiment 2

[0040] Prescription: Fimasartan 1g; PEG1500 5g;

[0041] PEG6000 25g; 1000 capsules in total.

[0042] Preparation method: Mix Fimasartan, PEG1500, and PEG6000 evenly, heat in a water bath to make it completely melt, pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the drip nozzle, and drop it into the In simethicone oil at -5°C, after molding, filter, separate, and wipe clean to obtain.

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Abstract

The invention discloses a fimasartan dropping pill for treating hypertension and a preparation method of the fimasartan dropping pill. The preparation method comprises the steps of with fimasartan as a raw material, adding a matrix according to a prescription, and uniformly mixing to obtain a mixed material; heating the mixed material to be molten, and uniformly stirring to obtain a mixture; placing the mixture into a special pill dropping machine; and dropping pills into a condensing agent at a proper speed to condense to form the fimasartan dropping pill. The fimasartan dropping pill is high in bioavailability, capable of rapidly releasing drugs, high in effect taking speed and drug stability and convenient to take; in addition, the consumption of auxiliary materials is reduced, the production process is simple, the preparation method is easy to operate, the weight difference is small, and the production cost is reduced; and no dust is generated, and labor protection can be favorably realized.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, specifically a Fimasartan dripping pill and a preparation method thereof. Background technique [0002] Fimasartan was developed by South Korea Boryeong Pharmaceutical Co., Ltd. and launched in South Korea in 2011. It is a new type of non-peptide angiotensin II receptor antagonist, which has the effect of selectively blocking AT1 receptors. Preclinical studies have shown that fimasartan is well tolerated, has a faster onset of antihypertensive effect and better antihypertensive effect than losartan. Compared with the results of other latest research on ARB drugs reducing siDBP or 24ABP, the reduction in siDBP in the fimasartan group was greater than other drugs, and the reduction in 24ABP was also comparable to that of olmesartan, which was the strongest ARB drug in reducing 24ABP. Fimasartan increases the activity of renin and angiotensin II. Fimasartan is rapidl...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/513A61P9/12
Inventor 黄四周李明亮王琦
Owner TIANJIN KANGRUI PHARMA
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