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Bone infection preventing and treating composite bone cement and preparation method thereof

A technology of bone cement and bone infection, applied in medical science, prosthesis and other directions, to achieve the effect of promoting the increase of bone density, avoiding antibiotic resistance, and having great clinical application value

Inactive Publication Date: 2015-04-15
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irrational use of antibiotics, drug-resistant bacteria are gradually increasing in clinical practice (such as drug-resistant Staphylococcus aureus MRSA, drug-resistant Staphylococcus epidermidis MRSE, etc.), it is difficult to apply conventional implanted antibiotic bone cement, so the development of new There is an urgent clinical need for anti-infective implants and fixation materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Mg-Ag alloy particles with a particle size of 3 mm (with a magnesium content of 99wt%) were mixed with a calcium phosphate bone cement matrix, and then a curing solution was added in proportion and mixed to obtain a composite bone cement. The content of Mg-Ag alloy particles in the obtained composite bone cement is 30wt%, the content of calcium phosphate bone cement matrix is ​​60wt%, and the amount of solidification liquid is 10wt%.

[0027] Biological safety: carry out biological evaluation according to the experimental method described in GB / T16886. The experimental results show that the composite bone cement prepared in this example has no obvious cytotoxicity and blood coagulation on osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0028] Antibacterial properties: Experimental strains were used: Staphylococcus epidermidis (S. epidermidis), methicillin-resistant Staphylococcus epidermidis (MRSE) an...

Embodiment 2

[0031] Mg-Cu alloy particles with a particle size of 2mm (with a magnesium content of 99.5wt%) were mixed with a calcium phosphate bone cement matrix, and then a curing solution was added in proportion and mixed to obtain a composite bone cement. The content of Mg-Cu alloy particles in the obtained composite bone cement is 30wt%, the content of calcium phosphate bone cement matrix is ​​55wt%, and the amount of solidification liquid is 15wt%.

[0032] Biological safety: carry out biological evaluation according to the experimental method described in GB / T16886. The experimental results show that the composite bone cement prepared in this example has no obvious cytotoxicity and blood coagulation on osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0033] Antibacterial properties: Experimental strains were used: Staphylococcus epidermidis (S. epidermidis), methicillin-resistant Staphylococcus epidermidis (MRSE) a...

Embodiment 3

[0036] The pure magnesium particles with a particle diameter of 0.5mm are mixed with the calcium phosphate bone cement matrix, and then the solidifying solution is added in proportion and mixed to obtain a composite bone cement. The content of pure magnesium particles in the obtained composite bone cement is 40wt%, the content of calcium phosphate bone cement matrix is ​​50wt%, and the amount of solidification liquid is 10wt%.

[0037] Biological safety: carry out biological evaluation according to the experimental method described in GB / T16886. The experimental results show that the composite bone cement prepared in this example has no obvious cytotoxicity and blood coagulation on osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0038] Antibacterial properties: Experimental strains were used: Staphylococcus epidermidis (S. epidermidis), methicillin-resistant Staphylococcus epidermidis (MRSE) and Staphylococc...

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Abstract

The present invention provides a bone infection preventing and treating composite bone cement, which comprises, by mass, 0.5-70 wt% of magnesium-based metal particles, 10-95 wt% of a calcium phosphate bone cement matrix, and 1-60 wt% of a curing liquid. According to the bone infection preventing and treating composite bone cement of the present invention, the calcium phosphate bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used antibiotic-loaded calcium phosphate bone cement matrix so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability is far higher than the antibacterial capability of the traditional bone cement and achieves the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement while the generation of the antibiotic resistance is avoided; the bone infection preventing and treating composite bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the composite bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

Description

technical field [0001] The invention relates to the field of biological preparations, in particular to a controllable slow-release composite bone cement for preventing and treating bone infection with the effect of increasing bone density and a preparation method thereof. Background technique [0002] With the increase of the aging population, the extension of life expectancy and the improvement of the quality of life, the clinical application of bone cement in orthopedics is becoming more and more extensive. Calcium phosphate cement (CPC) is a biodegradable carrier material and currently the only bone repair implant material that can self-cure and produce bone regeneration. It is a kind of inorganic material with various calcium phosphate salts as the main component, which is added with curing liquid when used, and has self-curing ability, degradation activity and osteogenesis activity under physiological conditions. In fracture surgery, immediate and reliable fixation of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/56
Inventor 曲新华戴尅戎李扬
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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