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A degradable metal antibacterial suture

A suture and metal technology, applied in the field of degradable metal antibacterial sutures, can solve the problems of foreign body reaction and long absorption time, and achieve the effect of promoting healing, small tissue reaction and good degradation rate

Active Publication Date: 2016-09-28
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to its long absorption time, it is often found that foreign body reactions occur

Method used

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  • A degradable metal antibacterial suture
  • A degradable metal antibacterial suture
  • A degradable metal antibacterial suture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] refer to figure 1 , the degradable metal antibacterial suture provided in this embodiment includes a magnesium-based metal wire 1, and the magnesium-based metal wire 1 is pure magnesium with a purity higher than 99.99wt%, a diameter of 0.5mm, a tested mechanical strength of 200Mpa, and an elongation of 20% . The end of the thread 1 is titanium-plated and sharpened to form the needle 2.

[0042] Biological safety: biological evaluation was carried out according to the experimental method described in GB / T16886. The experimental results show that the material of this example has no obvious cytotoxicity and coagulation property to fibroblasts, and no obvious sensitization, stimulation and genotoxicity.

[0043] In vivo animal experiments and material degradation:

[0044]Thirty 6-month-old SD rats were selected, and the back skin was prepared, and a 5 cm incision was made. They were randomly divided into groups A and B, 15 in each group. The degradable metal antibacte...

Embodiment 2

[0046] refer to figure 2 and image 3 , the degradable metal antibacterial suture provided in this embodiment includes a magnesium-based metal thread 1 and a needle 2, and the end 11 of the magnesium-based metal thread 1 is spherical. The magnesium-based metal wire 1 is a Mg-Zn-Ca alloy (magnesium content is 94 wt%), with a diameter of 0.4 mm. After testing, the mechanical strength is 180 Mpa and the elongation is 18%.

[0047] The needle head 2 is formed by two needle petals, the front ends of the two needle petals are connected together to form the needle tip of the needle head 2, and the surfaces of the two needle petals that are close to each other (which can be called the inner surface of the needle petals) are provided with mutually matching self-locking. The surface of the two needle petals that are close to each other is also provided with a groove, and the groove is communicated with the tail end of the needle petal. The grooves on the upper form a channel 21 that ...

Embodiment 3

[0057] The degradable metal antibacterial suture provided in this embodiment includes a magnesium-based metal thread 1 and a needle 2, and the tail end of the needle 2 is provided with a needle hole 20 that allows the thread to pass through. Needle 2 can be a straight needle ( Figure 4 d) or looper ( Figure 4 e).

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Abstract

The invention provides a degradable metal antibacterial suture, which includes one or more strands of silk threads. The silk threads are a magnesium based metal material with a magnesium content of 90-100wt%. The degradable metal antibacterial suture also includes a needle head connected to the silk thread end. The degradable metal antibacterial suture provided by the invention has good degradation rate, releases a variety of trace elements in the degradation process, can promote skin healing, has a local antibacterial effect, and has little tissue reaction.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a degradable metal antibacterial suture. Background technique [0002] Absorbable sutures have been used in the operating room for decades. At present, the commonly used absorbable sutures in clinical practice are mainly catgut and synthetic fibers, such as Dexon (PGA, polyglycolic acid), Maxon (polyethylene glycol carbonate), Vicryl (Polyglactin910, polylactic acid glycolic acid), PDS (Polydioxanone) , polydioxanone) and PVA (polyvinyl acetate), etc. For example, CN1363397A discloses a manufacturing process of goat intestine medical biological suture. The washed goat casing is evenly longitudinally broken into 2-4 strips, and the inner wall of the casing is washed and soaked in 10-30% sodium hydroxide solution. ; Take out and wash, bleach with 0.1-0.4% hydrogen peroxide at room temperature for 4-8 hours, and apply animal collagen on the surface after taking out to achieve softness of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/06
Inventor 戴尅戎曲新华
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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