Integral engineering rack of interface osteochondro tissue with bionic function

Abstract

The invention discloses an osteochondral composite tissue integrated engineering support with bionic function interface, which is composed of cartilage layer, calcification layer and subchondral bone layer from top to bottom, between the cartilage layer and calcification layer, calcification layer and subchondral bone The organic connection between the layers; the cartilage layer is composed of type II collagen and chitosan, and type II collagen / chitosan is connected in the form of covalent bonds; the composition of the calcified layer is type II collagen and hydroxyapatite, II Type I collagen / hydroxyapatite are connected by covalent bonds; the subchondral bone layer is composed of type I collagen and hydroxyapatite, and type I collagen / hydroxyapatite are connected by covalent bonds; the cartilage layer and More than one pore is provided in the subchondral bone layer, and the pore diameter of the pore is 100 μm to 500 μm. The stent of the present invention has good biocompatibility, controllable degradability and sufficient mechanical strength, and has a bionic functional interface; after being transplanted into the patient's body, it can withstand the stress of the normal state and meet the mechanical requirements of the implanted site; The rate of degradation and absorption matches the growth rate of new tissue in the host.

Description

technical field [0001] The invention relates to a tissue engineering support for repairing human joint osteochondral defects, in particular to an integrated engineering support for osteochondral composite tissue with a bionic function interface. Background technique [0002] Osteochondral defects at the end of movable joints caused by trauma, infection, and degeneration are common orthopedic clinical diseases, often manifested as intractable pain, joint movement disorders, and severe cases may cause loss of motor function. According to statistics, the incidence of articular osteochondral defects in the United States is about 1.5‰ to 3‰, and it is 5 to 6 times that in my country. Because articular cartilage has no blood vessels, nerves, and lymphatic systems, osteochondral defects with a diameter of more than 2 mm to 4 mm can hardly be completely repaired. The existing treatment methods all have obvious defects, and it is difficult to make them truly achieve natural repair a...

AI Technical Summary

Problems solved by technology

[0007] The present invention aims at the lack of ideal functional interface in the osteochondral composite tissue constructed in the prior art; there are defects in the quality of the reconstructed tissue, poor integration of the graft and the host, and poor mechanical strength, etc., and provides a good biocompatibility, Osteochondral composite tissue integrated engineering scaffold with controllable degradability, sufficient mechanical strength and biomimetic functional interface

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