Excipient-free lyophilized paclitaxel powder preparation and preparation method thereof
A technology of paclitaxel and freeze-dried powder, applied in freeze-dried delivery, powder delivery, anti-tumor drugs and other directions, can solve the problems of large particle size and complicated process, and achieve the effects of simple formula, good solubility and high safety
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[0043] A paclitaxel freeze-dried powder preparation without excipients is prepared through the following process.
[0044]① Weigh raw materials according to different feeding ratios (paclitaxel: mPEG-PLA-glutamic acid). Among them, the raw material paclitaxel (CAS33069-62-4) is produced by Xi'an Ruilin Biotechnology Co., Ltd., the purity is greater than 95%, and the raw material mPEG-PLA-glutamic acid is produced by the inventor according to the process described in the patent number PCT-CN-2013000453 self-preparation;
[0045] ②Put the above-mentioned raw materials into a container, and add organic solvents such as ethanol or acetonitrile at a temperature of 15-45°C until they are completely dissolved. The dissolving process can adopt means such as stirring or shaking.
[0046] ③ Rotate the above solution at 30-50°C for 2 hours until the organic solvent evaporates to dryness. Then vacuum drying at 10-40° C. for > 12 hours to remove residual organic solvents to obtain a pac...
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